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MIRAGE
High affinity immunoglobulin gamma Fc receptor I

Summary
UniProt ID
P12314
Gene Symbol
  • FCG1
  • FCGR1
  • FCGR1A
  • IGFR1
Gene ID
2209
Organism
Homo sapiens (human)
GlyGen
P12314
PubChem
P12314
Re-Glyco
P12314
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • IgG-binding protein
  • Immunoglobulin domain
  • Innate immunity
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 4 entries
GO Term
plasma membrane
external side of plasma membrane
early endosome membrane
clathrin-coated endocytic vesicle membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 8 entries
Position Description PubMed ID GlyTouCan ID Source
59 N-linked (GlcNAc...) asparagine
78 N-linked (GlcNAc...) asparagine
152 N-linked (GlcNAc...) asparagine
159 N-linked (GlcNAc...) asparagine
163 N-linked (GlcNAc...) asparagine
195 N-linked (GlcNAc...) asparagine
240 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 7 entries
Pathway Name Organism
Cross-presentation of soluble exogenous antigens (endosomes) Homo sapiens
FCGR activation Homo sapiens
FCGR3A-mediated IL10 synthesis Homo sapiens
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens
Interferon gamma signaling Homo sapiens
Regulation of actin dynamics for phagocytic cup formation Homo sapiens
Role of phospholipids in phagocytosis Homo sapiens
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025