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High affinity immunoglobulin epsilon receptor subunit alpha

Summary

UniProt ID

P12319

Gene Symbol

FCE1A
FCER1A

Gene ID

[2205]

Organism

Homo sapiens (human)

External Links

GlyGen: P12319
PubChem: P12319
Re-Glyco: P12319

Annotation

Keyword: 3D-structure Cell membrane Direct protein sequencing Disulfide bond Glycoprotein IgE-binding protein Immunoglobulin domain Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
cell surface receptor signaling pathway	IBA	GO_REF
immunoglobulin mediated immune response	IBA	GO_REF
type I hypersensitivity	IMP	PMID
type 2 immune response	IDA	PMID
mast cell degranulation	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

type I hypersensitivity

leukocyte degranulation [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

type I hypersensitivity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type I hypersensitivity

type 2 immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type I hypersensitivity

acute inflammatory response [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type I hypersensitivity

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

type I hypersensitivity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type I hypersensitivity

type 2 immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

establishment of localization in cell [inference]

leukocyte degranulation [inference]

establishment of organelle localization [inference]

mast cell degranulation

organelle localization [inference]

establishment of organelle localization [inference]

mast cell degranulation

vacuolar localization [inference]

lysosome localization [inference]

mast cell degranulation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	Reference
plasma membrane	TAS	PMID Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
plasma membrane	IDA	PMID PMID
plasma membrane	IEA	GO_REF
external side of plasma membrane	IBA	GO_REF
cell surface	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
high-affinity IgE receptor activity	IDA	PMID PMID
high-affinity IgE receptor activity	IBA	GO_REF
IgE binding	IDA	PMID
IgE binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgE binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

immunoglobulin receptor activity [inference]

IgE receptor activity [inference]

high-affinity IgE receptor activity

immune receptor activity [inference]

immunoglobulin receptor activity [inference]

IgE receptor activity [inference]

high-affinity IgE receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	Source
46	N-linked (GlcNAc...) asparagine	10917520 11531339 9875849	UniProt GlyGen
67	N-linked (GlcNAc...) asparagine	10917520 11531339 9875849	UniProt GlyGen
75	N-linked (GlcNAc...) asparagine		UniProt GlyGen
99	N-linked (GlcNAc...) asparagine	11531339	UniProt GlyGen
160	N-linked (GlcNAc...) asparagine		UniProt GlyGen
165	N-linked (GlcNAc...) asparagine	11531339	UniProt GlyGen
191	N-linked (GlcNAc...) asparagine	10917520 11531339 9875849	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
FCERI mediated Ca+2 mobilization	Homo sapiens
FCERI mediated MAPK activation	Homo sapiens
FCERI mediated NF-kB activation	Homo sapiens
Fc epsilon receptor (FCERI) signaling	Homo sapiens
Role of LAT2/NTAL/LAB on calcium mobilization	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements