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3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Summary

UniProt ID

P12683

Gene Symbol

HMG1
YML075C

Gene ID

[854900]

Organism

Saccharomyces cerevisiae S288C

External Links

PubChem: P12683
The Human Metabolome Database: HMDBP13620
Re-Glyco: P12683

Annotation

Keyword: Endoplasmic reticulum Glycoprotein NADP Nucleus Oxidoreductase Phosphoprotein Reference proteome Sterol biosynthesis Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
ergosterol biosynthetic process	RCA	GO_REF
ergosterol biosynthetic process	IDA	PMID
ergosterol biosynthetic process	IMP	PMID
ergosterol biosynthetic process	IBA	GO_REF
ergosterol biosynthetic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

coenzyme A metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

coenzyme A metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

coenzyme A metabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

isoprenoid biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

coenzyme A metabolic process

lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

sterol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

sterol biosynthetic process [inference]

ergosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

ergosterol biosynthetic process

phytosteroid biosynthetic process [inference]

ergosterol biosynthetic process

isoprenoid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

secondary alcohol metabolic process [inference]

ergosterol metabolic process [inference]

ergosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

ergosterol biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

coenzyme A metabolic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
nuclear envelope	EXP	PMID
nuclear envelope	IDA	PMID
nuclear envelope	IEA	GO_REF GO_REF
peroxisomal membrane	IBA	GO_REF
endoplasmic reticulum	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle envelope [inference]

nuclear envelope

nuclear periphery

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
hydroxymethylglutaryl-CoA reductase (NADPH) activity	RCA	GO_REF
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IMP	PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IGI	PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPPLFKGLKQMAKPIAYVSRFSAKRPIHIILFSLIISAFAYLSVIQYYFNGWQLDSNSVFETAPNKDSNTLFQECSHYYRDSSLDGWVSITAHEASELPAPHHYYLLNLNFNSPNETDSIPELANTVFEKDNTKYILQEDLSVSKEISSTDGTKWRLRSDRKSLFDVKTLAYSLYDVFSENVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLALYVTQCILGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYALEKFERVGLSKRITTDEIVFESVSEEGGRLIQDHLLCIFAFIGCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILALRLEMNVIHRSTIIKQTLEEDGVVPSTARIISKAEKKSVSSFLNLSVVVIIMKLSVILLFVFINFYNFGANWVNDAFNSLYFDKERVSLPDFITSNASENFKEQAIVSVTPLLYYKPIKSYQRIEDMVLLLLRNVSVAIRDRFVSKLVLSALVCSAVINVYLLNAARIHTSYTADQLVKTEVTKKSFTAPVQKASTPVLTNKTVISGSKVKSLSSAQSSSSGPSSSSEEDDSRDIESLDKKIRPLEELEALLSSGNTKQLKNKEVAALVIHGKLPLYALEKKLGDTTRAVAVRRKALSILAEAPVLASDRLPYKNYDYDRVFGACCENVIGYMPLPVGVIGPLVIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSEEGQNAIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLVGSAMAGSVGGFNAHAANLVTAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGHLVQSHMTHNRKPAEPTKPNNLDATDINRLKDGSVTCIKS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
115	N-linked (GlcNAc...) asparagine	UniProt
181	N-linked (GlcNAc...) asparagine	UniProt
452	N-linked (GlcNAc...) asparagine	UniProt
490	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Lanosterol biosynthesis	Saccharomyces cerevisiae

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements