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Farnesyl pyrophosphate synthase

Summary

UniProt ID: P14324
Gene Symbol: FDPS FPS KIAA1293
Gene ID: 2224
Organism: Homo sapiens (human)

External Links

GlyGen

P14324

PubChem

P14324

SwissLipids

The Human Metabolome Database

HMDBP00932

The O-GlcNAc Database

P14324

RaftProt

P14324

O-GlcNAcAtlas

P14324

Re-Glyco

P14324

Annotation

Keyword: 3D-structure Acetylation Alternative splicing Cholesterol biosynthesis Cytoplasm Disease variant Host-virus interaction Hydroxylation Isoprene biosynthesis Magnesium Metal-binding Proteomics identification Reference proteome Transferase

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
cholesterol biosynthetic process	TAS	PMID
cholesterol biosynthetic process	IEA	GO_REF
geranyl diphosphate biosynthetic process	IEA	GO_REF
farnesyl diphosphate biosynthetic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
nucleoplasm
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF GO_REF
mitochondrial matrix	IDA	PMID
peroxisome	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
RNA binding	HDA	PMID
dimethylallyltranstransferase activity	EXP	PMID
dimethylallyltranstransferase activity	IEA	GO_REF GO_REF GO_REF
(2E,6E)-farnesyl diphosphate synthase activity	EXP	PMID
(2E,6E)-farnesyl diphosphate synthase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity [inference]

prenyl diphosphate synthase activity [inference]

binding [inference]

nucleic acid binding [inference]

RNA binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
4		33465208 34019948 34725712 38665916 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Activation of gene expression by SREBF (SREBP)	Homo sapiens
Lanosterol biosynthesis	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3805	porokeratosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

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International Collaboration

Acknowledgements