GlyCosmos Portal

Submissions

Cadherin-2

Summary

UniProt ID: P15116
Gene Symbol: Cdh2
Gene ID: 12558
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003396

GlyConnect

Cadherin-2

GlyGen

P15116

PubChem

P15116

Re-Glyco

P15116

Annotation

Keyword: 3D-structure Calcium Cell adhesion Cell junction Cell membrane Cell projection Cleavage on pair of basic residues Glycoprotein Metal-binding Phosphoprotein Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 49 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	Reference
cell morphogenesis	IBA	GO_REF
type B pancreatic cell development	IMP	PMID
cell-cell junction assembly	IMP	PMID
cell-cell junction assembly	IBA	GO_REF
cell adhesion	IDA	PMID PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

radial glial cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation

cell development [inference]

epithelial cell development [inference]

type B pancreatic cell development

stem cell development [inference]

neural crest cell development

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

mesenchymal cell migration

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction organization [inference]

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

animal organ morphogenesis [inference]

brain morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

type B pancreatic cell development

stem cell development [inference]

neural crest cell development

animal gross anatomical part developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

radial glial cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation

cell development [inference]

epithelial cell development [inference]

type B pancreatic cell development

stem cell development [inference]

neural crest cell development

maintenance of cell number [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of protein localization

regulation of protein localization to membrane [inference]

regulation of postsynaptic density protein 95 clustering

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of synaptic vesicle clustering

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of postsynaptic density protein 95 clustering

regulation of synaptic vesicle clustering [inference]

positive regulation of synaptic vesicle clustering

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of transport [inference]

positive regulation of synaptic vesicle clustering

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of myelination

regulation of cell population proliferation [inference]

regulation of neural precursor cell proliferation [inference]

regulation of oligodendrocyte progenitor proliferation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis

regulation of organelle organization [inference]

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density protein 95 clustering

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density protein 95 clustering

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of postsynaptic density protein 95 clustering

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination

Displaying entries **1 - 5** of 51 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	Reference
cytoplasm	ISO	GO_REF
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF
plasma membrane	ISO	GO_REF GO_REF
plasma membrane	EXP	PMID

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

sarcolemma

plasma membrane region [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

cell junction

synapse

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

cell-cell contact zone [inference]

intercalated disc

T-tubule

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

Displaying entries **1 - 5** of 19 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	Reference
RNA binding	IDA	PMID
calcium ion binding	IDA	PMID
calcium ion binding	IEA	GO_REF
beta-catenin binding	ISO	GO_REF GO_REF
beta-catenin binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding [inference]

beta-catenin binding

enzyme binding

kinase binding [inference]

protein kinase binding

protein tyrosine kinase binding

phosphatase binding [inference]

protein phosphatase binding

nitric-oxide synthase binding

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 18 in total

1

2

Next ›

Last »
Position	Description	PubMed ID	GlyTouCan ID	Source
120			G83460ZZ	GlyGen
190	N-linked (GlcNAc...) asparagine	30899004	G02815KT G06110VR	UniProt GlyGen GlyConnect
273	N-linked (GlcNAc...) asparagine	21300292		UniProt GlyGen
290				GlyGen
315				GlyGen
325	N-linked (GlcNAc...) asparagine	21300292	G40834TG	GlycoProtDB UniProt GlyGen
365				GlyGen
367				GlyGen
402	N-linked (GlcNAc...) asparagine	21300292	G20528HD	UniProt GlyGen
481				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Adherens junctions interactions	Mus musculus
Myogenesis	Mus musculus
Post-translational protein phosphorylation	Mus musculus
Regulation of IGF Activity by IGFBP	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements