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MIRAGE
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Summary
UniProt ID
P16118
Gene Symbol
  • F6PK
  • PFKFB1
  • PFRX
Gene ID
5207
Organism
Homo sapiens (human)
GlyGen
P16118
PubChem
P16118
The Human Metabolome Database
HMDBP00799
The O-GlcNAc Database
P16118
O-GlcNAcAtlas
P16118
Re-Glyco
P16118
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Alternative splicing
  • Hydrolase
  • Kinase
  • Multifunctional enzyme
  • Phosphoprotein
  • Reference proteome
Gene Ontology (GO)
Displaying all 2 entries
GO Term
cytosol
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
2
9
250
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
PKA-mediated phosphorylation of key metabolic factors Homo sapiens
PP2A-mediated dephosphorylation of key metabolic factors Homo sapiens
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Homo sapiens
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025