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11-beta-hydroxysteroid dehydrogenase 1

Summary

UniProt ID

P16232

Gene Symbol

Hsd11b1
Hsd11

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P16232

Annotation

Keyword

Alternative promoter usage
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
NADP
Oxidoreductase
Reference proteome
Signal-anchor
Steroid metabolism
Transmembrane helix

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
glucocorticoid biosynthetic process
steroid catabolic process
glucocorticoid catabolic process
mineralocorticoid metabolic process
lung development
response to nutrient levels
cellular response to estradiol stimulus
regulation of pentose-phosphate shunt

Displaying **all 4** entries
GO Term
nuclear membrane
intracellular membrane-bounded organelle
apical part of cell
endoplasmic reticulum membrane

Displaying **all 6** entries
GO Term
NADP binding
protein homodimerization activity
7-beta-hydroxysteroid dehydrogenase (NADP+) activity
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
cortisol dehydrogenase activity
steroid binding

Annotation information from UniProt.

Sequence

MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites