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MIRAGE
Vascular endothelial growth factor A
Summary
- UniProt ID
- P16612
- Gene Symbol
- Vegf Vegfa
- Gene ID
- 83785
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Alternative splicing Angiogenesis Developmental protein Differentiation Direct protein sequencing Disulfide bond Glycoprotein Growth factor Heparin-binding Mitogen Reference proteome Secreted Signal
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| angiogenesis | ||
| angiogenesis | ||
| angiogenesis | ||
| angiogenesis |
GO Hierarchy
- positive regulation of cell division
- positive regulation of cell division
biological process
cellular process [inference]
signal transduction [inference]
multicellular organismal process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of growth
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of locomotion [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of metabolic process [inference]
positive regulation of cell motility [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation [inference]
positive regulation of cell population proliferation
regulation of cellular component biogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of metabolic process [inference]
positive regulation of cell motility [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
positive regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| basement membrane | ||
| obsolete extracellular space |
|
|
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| fibronectin binding | ||
| signaling receptor binding | ||
| cytokine activity | ||
| platelet-derived growth factor receptor binding | ||
| vascular endothelial growth factor receptor binding |
Sequence
MNFLLSWVHWTLALLLYLHHAKWSQAAPTTEGEQKAHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPEKKSVRGKGKGQKRKRKKSRFKSWSVHCEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 100 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Platelet degranulation | Rattus norvegicus |
| VEGF binds to VEGFR leading to receptor dimerization | Rattus norvegicus |
| VEGF ligand-receptor interactions | Rattus norvegicus |
| VEGFA-VEGFR2 Pathway | Rattus norvegicus |
| VEGFR2 mediated cell proliferation | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11396 | pulmonary edema | |
| DOID:5425 | ovarian hyperstimulation syndrome | |
| DOID:0050852 | limb ischemia | |
| DOID:13207 | proliferative diabetic retinopathy | |
| DOID:4724 | brain edema | |
| DOID:1686 | glaucoma | |
| DOID:5844 | myocardial infarction | |
| DOID:3525 | middle cerebral artery infarction |
