GlyCosmos Portal

Submissions

Lysosome-associated membrane glycoprotein 2

Summary

UniProt ID: P17047
Gene Symbol: Lamp-2 Lamp2
Gene ID: 16784
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003438

GlyConnect

Lysosome-associated membrane glycoprotein 2

GlyGen

P17047

PubChem

P17047

RaftProt

P17047

Re-Glyco

P17047

Annotation

Keyword: 3D-structure Alternative splicing Autophagy Cell membrane Cytoplasmic vesicle Disulfide bond Endosome Glycoprotein Lysosome Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	Reference
protein targeting	IMP	PMID PMID
autophagy	IMP	PMID
lysosomal lumen acidification	ISS	GO_REF
lysosomal lumen acidification	ISO	GO_REF
lysosomal lumen acidification	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

autophagy

chaperone-mediated autophagy

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

process utilizing autophagic mechanism [inference]

autophagy

chaperone-mediated autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular pH elevation [inference]

lysosomal lumen pH elevation

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular pH elevation [inference]

lysosomal lumen pH elevation

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular pH elevation [inference]

lysosomal lumen pH elevation

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular pH elevation [inference]

lysosomal lumen pH elevation

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular pH elevation [inference]

lysosomal lumen pH elevation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein localization to lysosome [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

establishment of protein localization [inference]

protein targeting

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular pH elevation [inference]

lysosomal lumen pH elevation

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of cellular process [inference]

regulation of programmed cell death [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

regulation of ferroptosis [inference]

positive regulation of ferroptosis

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of biological quality [inference]

regulation of protein stability

protein stabilization

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular pH elevation [inference]

lysosomal lumen pH elevation

Displaying entries **1 - 5** of 41 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	Reference
autophagosome membrane	IDA	PMID
autophagosome membrane	IBA	GO_REF
autophagosome membrane	IEA	GO_REF GO_REF
obsolete extracellular space
lysosome	ISO	PMID PMID GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

chaperone-mediated autophagy translocation complex

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

platelet dense granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

platelet dense granule membrane

membrane microdomain [inference]

membrane raft

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

secondary lysosome [inference]

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

secondary lysosome [inference]

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
ion channel inhibitor activity	ISS	GO_REF
ion channel inhibitor activity	ISO	GO_REF
ion channel inhibitor activity	IEA	GO_REF
enzyme binding	ISO	GO_REF
enzyme binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

signaling adaptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MCLSPVKGAKLILIFLFLGAVQSNALIVNLTDSKGTCLYAEWEMNFTITYETTNQTNKTITIAVPDKATHDGSSCGDDRNSAKIMIQFGFAVSWAVNFTKEASHYSIHDIVLSYNTSDSTVFPGAVAKGVHTVKNPENFKVPLDVIFKCNSVLTYNLTPVVQKYWGIHLQAFVQNGTVSKNEQVCEEDQTPTTVAPIIHTTAPSTTTTLTPTSTPTPTPTPTPTVGNYSIRNGNTTCLLATMGLQLNITEEKVPFIFNINPATTNFTGSCQPQSAQLRLNNSQIKYLDFIFAVKNEKRFYLKEVNVYMYLANGSAFNISNKNLSFWDAPLGSSYMCNKEQVLSVSRAFQINTFNLKVQPFNVTKGQYSTAQDCSADEDNFLVPIAVGAALGGVLILVLLAYFIGLKRHHTGYEQF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 21 in total

1

2

3

Next ›

Last »
Position	Description	PubMed ID	GlyTouCan ID	Source
29	N-linked (GlcNAc...) asparagine	27663661	G12959FT	GlycoProtDB UniProt GlyGen
45	N-linked (GlcNAc...) asparagine	27663661		GlycoProtDB UniProt GlyGen
54	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
57	N-linked (GlcNAc...) asparagine	27663661		GlycoProtDB UniProt GlyGen
97	N-linked (GlcNAc...) asparagine	27663661		UniProt GlyGen
115	N-linked (GlcNAc...) asparagine	27663661 30899004	G80920RR G50045TK G33609NS G06110VR G66538GV G14669DU	GlycoProtDB UniProt GlyGen GlyConnect
156		30899004	G06110VR G00406II G84349RE G66538GV G74724QE	GlycoProtDB GlyGen GlyConnect
175	N-linked (GlcNAc...) asparagine	30899004	G74724QE G31685JQ G06130KI	GlycoProtDB UniProt GlyGen GlyConnect
218				GlyGen
220				GlyGen