GlyCosmos Portal

Submissions

Sphingomyelin phosphodiesterase

Summary

UniProt ID: P17405
Gene Symbol: SMPD1 ASM
Gene ID: 6609
Organism: Homo sapiens (human)

External Links

GlyConnect

Sphingomyelin phosphodiesterase

GlyGen

P17405

PubChem

P17405

SwissLipids

SLP:000001748

The Human Metabolome Database

HMDBP00776

Re-Glyco

P17405

Annotation

Keyword: 3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Glycoprotein Glycosidase Host-virus interaction Lipid droplet Lipid metabolism Lysosome Metal-binding Neurodegeneration Niemann-Pick disease Phosphoprotein Proteomics identification Reference proteome Secreted Signal Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	Reference
plasma membrane repair	IDA	PMID
plasma membrane repair	IEA	GO_REF GO_REF
sphingomyelin metabolic process	TAS	PMID
sphingomyelin catabolic process	IDA	PMID PMID PMID
sphingomyelin catabolic process	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

catabolic process [inference]

lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process

sphingomyelin catabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane repair

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

response to ionizing radiation

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

response to chemical [inference]

response to xenobiotic stimulus

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

response to peptide [inference]

response to cytokine [inference]

response to nitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation of transport [inference]

positive regulation of endocytosis

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
obsolete extracellular space
lysosome	IDA	PMID PMID PMID PMID PMID PMID PMID PMID PMID
lysosome	IBA	GO_REF
lysosome	IEA	GO_REF
endosome	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

endolysosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

endolysosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

endolysosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

intracellular membraneless organelle [inference]

lipid droplet

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
sphingomyelin phosphodiesterase activity	EXP	PMID PMID PMID PMID PMID PMID PMID PMID
sphingomyelin phosphodiesterase activity	TAS	PMID Reactome Reactome
sphingomyelin phosphodiesterase activity	IDA	PMID PMID PMID PMID
sphingomyelin phosphodiesterase activity	IEA	GO_REF GO_REF GO_REF
zinc ion binding	IDA	PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

C-type glycerophospholipase activity [inference]

phosphatidylcholine phospholipase C activity

sphingophospholipase activity [inference]

sphingomyelin phosphodiesterase activity

acid sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

C-type glycerophospholipase activity [inference]

phosphatidylcholine phospholipase C activity

sphingomyelin phosphodiesterase activity

acid sphingomyelin phosphodiesterase activity

hydrolase activity, acting on glycosyl bonds

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
88	N-linked (GlcNAc...) asparagine	27349982 29671580 9030779	G36670VW G91473PK G08290VR	UniProt GlyGen GlyConnect
177	N-linked (GlcNAc...) asparagine	27349982 9030779		UniProt GlyGen
337	N-linked (GlcNAc...) asparagine	27349982 9030779	G43769HG	UniProt GlyGen
383				GlyGen
397	N-linked (GlcNAc...) asparagine	27349982 9030779		UniProt GlyGen
440				GlyGen
505	N-linked (GlcNAc...) asparagine	27349982		UniProt GlyGen
522	N-linked (GlcNAc...) asparagine	27349982 9030779		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Glycosphingolipid catabolism	Homo sapiens
Regulation of clotting cascade	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070112	Niemann-Pick disease type B	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0070111	Niemann-Pick disease type A	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:14504	Niemann-Pick disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements