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MIRAGE

DNA sliding clamp PCNA

Summary

UniProt ID: P17917
Gene Symbol: CG9193 PCNA PCNA1 mus209
Gene ID: 37290
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: P17917
The O-GlcNAc Database: P17917
Re-Glyco: P17917

Annotation

Keyword: 3D-structure Chromosome Cytoplasm DNA replication DNA-binding Direct protein sequencing Nucleus Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
DNA replication	TAS	PMID
DNA replication	IMP	PMID
DNA-templated DNA replication	TAS	PMID
leading strand elongation	IBA	GO_REF
nucleotide-excision repair	TAS	PMID

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA damage tolerance [inference]

translesion synthesis

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA damage tolerance [inference]

translesion synthesis

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA amplification [inference]

eggshell chorion gene amplification

DNA synthesis involved in DNA replication [inference]

translesion synthesis

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

cellular process involved in reproduction in multicellular organism [inference]

eggshell chorion gene amplification

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

DNA damage tolerance [inference]

translesion synthesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

reproductive process [inference]

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

eggshell chorion gene amplification

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

DNA damage tolerance [inference]

translesion synthesis

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

response to chemical [inference]

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to methyl methanesulfonate

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

DNA damage tolerance [inference]

translesion synthesis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

regulation of DNA repair [inference]

positive regulation of DNA repair

positive regulation of DNA metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

regulation of DNA repair [inference]

positive regulation of DNA repair

positive regulation of DNA metabolic process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
chromatin	IDA	PMID
nucleus	EXP	PMID
nucleus	IDA	PMID
nucleus	IMP	PMID
nucleus	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

PCNA complex

enzyme activator complex [inference]

DNA polymerase processivity factor complex [inference]

PCNA complex

cellular anatomical structure [inference]

chromatin

replication fork [inference]

nuclear replication fork

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	Reference
DNA binding	IEA	GO_REF
chromatin binding	IDA	PMID
chromatin binding	IEA	GO_REF
DNA polymerase processivity factor activity	IBA	GO_REF
DNA polymerase processivity factor activity	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

DNA binding

chromatin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

DNA polymerase processivity factor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

DNA polymerase processivity factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFEARLGQATILKKILDAIKDLLNEATFDCSDSGIQLQAMDNSHVSLVSLTLRSDGFDKFRCDRNLSMGMNLGSMAKILKCANNEDNVTMKAQDNADTVTIMFESANQEKVSDYEMKLMNLDQEHLGIPETDFSCVVRMPAMEFARICRDLAQFSESVVICCTKEGVKFSASGDVGTANIKLAQTGSVDKEEEAVIIEMQEPVTLTFACRYLNAFTKATPLSTQVQLSMCADVPLVVEYAIKDLGHIRYYLAPKIEDNET

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
185		40245499	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 14 in total

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Pathway Name	Organism
Dual Incision in GG-NER	Drosophila melanogaster
Dual incision in TC-NER	Drosophila melanogaster
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	Drosophila melanogaster
PCNA-Dependent Long Patch Base Excision Repair	Drosophila melanogaster
Polymerase switching	Drosophila melanogaster
Processive synthesis on the lagging strand	Drosophila melanogaster
Recognition of DNA damage by PCNA-containing replication complex	Drosophila melanogaster
Removal of the Flap Intermediate	Drosophila melanogaster
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	Drosophila melanogaster
Termination of translesion DNA synthesis	Drosophila melanogaster

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026