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Protein serrate

Summary

UniProt ID: P18168
Gene Symbol: Bd CG6127 Rpw Ser
Gene ID: 43275
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: P18168
Re-Glyco: P18168

Annotation

Keyword: 3D-structure Cell membrane Cell projection Cytoplasm Developmental protein Differentiation Disulfide bond EGF-like domain Endosome Glycoprotein Phosphoprotein Reference proteome Repeat Signal Transmembrane helix Ubl conjugation

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
Notch signaling pathway	IMP	PMID PMID PMID PMID PMID PMID PMID PMID
Notch signaling pathway	IGI	PMID PMID PMID
Notch signaling pathway	IEA	GO_REF
sensory organ development	IMP	PMID
salivary gland morphogenesis	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cellular process [inference]

cell cycle [inference]

mitotic cell cycle [inference]

second mitotic wave involved in compound eye morphogenesis

cell communication [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell population proliferation [inference]

glial cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

wing disc pattern formation [inference]

wing disc anterior/posterior pattern formation

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

cuticle pattern formation

segmentation [inference]

appendage segmentation [inference]

imaginal disc-derived leg segmentation

stem cell population maintenance [inference]

germ-line stem cell population maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

larval salivary gland morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

animal organ development [inference]

sensory organ development

eye development [inference]

compound eye development

imaginal disc development [inference]

eye-antennal disc development

cellular developmental process [inference]

cell differentiation [inference]

hemocyte differentiation [inference]

crystal cell differentiation

cell development [inference]

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

maintenance of cell number [inference]

stem cell population maintenance [inference]

germ-line stem cell population maintenance

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal process [inference]

regulation of hemocyte differentiation [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

negative regulation of hemocyte differentiation [inference]

negative regulation of lamellocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of lamellocyte differentiation [inference]

negative regulation of lamellocyte differentiation

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome
plasma membrane	IDA	PMID PMID
plasma membrane	IEA	GO_REF
cell surface	IDA	PMID
cell surface	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

apical cortex

cytoplasmic region [inference]

cell cortex region [inference]

apical cortex

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

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GO Term	Evidence Code	Reference
Notch binding	IDA	PMID PMID PMID
Notch binding	IBA	GO_REF
Notch binding	IPI	PMID
Notch binding	IEA	GO_REF
calcium ion binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

Notch binding

lipid binding [inference]

sphingolipid binding [inference]

glycosphingolipid binding

glycolipid binding [inference]

glycosphingolipid binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MYKMFRKHFRRKPATSSSLESTIESADSLGMSKKTATKRQRPRHRVPKIATLPSTIRDCRSLKSACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGMELSLNPAPELAASAASSSALHRSQPLFPPCDFERELDSSTGLKQAHKRSSQILLHKTQNSDMRKNTVGSLDSPRKDFGKRSINCKSMPPSSGDEGSDVLATTVMV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
151	N-linked (GlcNAc...) asparagine	UniProt
195	N-linked (GlcNAc...) asparagine	UniProt
246	N-linked (GlcNAc...) asparagine	UniProt
330	N-linked (GlcNAc...) asparagine	UniProt
411	N-linked (GlcNAc...) asparagine	UniProt
451	N-linked (GlcNAc...) asparagine	UniProt
557	N-linked (GlcNAc...) asparagine	UniProt
738	N-linked (GlcNAc...) asparagine	UniProt
964	N-linked (GlcNAc...) asparagine	UniProt
976	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
NOTCH2 Activation and Transmission of Signal to the Nucleus	Drosophila melanogaster
RAC1 GTPase cycle	Drosophila melanogaster
RAC3 GTPase cycle	Drosophila melanogaster

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements