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Prothrombin
Summary
- UniProt ID
- P18292
- Gene Symbol
- F2
- Gene ID
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Acute phase Blood coagulation Calcium Cleavage on pair of basic residues Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Kringle Reference proteome Repeat Serine protease Signal Zymogen
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| proteolysis | ||
| proteolysis | ||
| acute-phase response |
|
|
| cell surface receptor signaling pathway | ||
| G protein-coupled receptor signaling pathway |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of transmembrane transport [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| obsolete extracellular space |
|
|
| external side of plasma membrane | ||
| extracellular matrix | ||
| extracellular matrix |
| GO Term | Evidence Code | Reference |
|---|---|---|
| lipopolysaccharide binding | ||
| endopeptidase activity | ||
| serine-type endopeptidase activity | ||
| serine-type endopeptidase activity | ||
| serine-type endopeptidase activity |
GO Hierarchy
Sequence
MLHVRGLGLPGCLALAALASLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGLNYHGNVSVTHTGIECQLWRSRYPHRPDINSTTHPGADLKENFCRNPDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSKENLSPPLGECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEVKLVQNFCRNPDRDEEGAWCFVAQQPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVIDQHR
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Amplification and propagation of coagulation cascade | Rattus norvegicus |
| Cell surface interactions at the vascular wall | Rattus norvegicus |
| Fibrin formation | Rattus norvegicus |
| G alpha (q) signalling events | Rattus norvegicus |
| Gamma-carboxylation of protein precursors | Rattus norvegicus |
| Initiation of coagulation cascade | Rattus norvegicus |
| Peptide ligand-binding receptors | Rattus norvegicus |
| Regulation of Complement cascade | Rattus norvegicus |
| Regulation of IGF Activity by IGFBP | Rattus norvegicus |
| Regulation of clotting cascade | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:2452 | thrombophilia | |
| DOID:0060903 | thrombosis | |
| DOID:783 | end stage renal disease | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:9970 | obesity | |
| DOID:9279 | hyperhomocysteinemia | |
| DOID:3070 | high grade glioma | |
| DOID:2527 | nephrosis | |
| DOID:1936 | atherosclerosis |
