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Protein patched

Summary

UniProt ID: P18502
Gene Symbol: CG2411 ptc
Gene ID: 35851
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: P18502
Re-Glyco: P18502

Annotation

Keyword: Glycoprotein Receptor Reference proteome Segmentation polarity protein Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
Bolwig's organ morphogenesis	IMP	PMID
regulation of mitotic cell cycle	IMP	PMID
segment polarity determination
axon guidance	IMP	PMID
eye-antennal disc morphogenesis	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell fate commitment [inference]

determination of imaginal disc primordium [inference]

determination of genital disc primordium

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

follicle cell of egg chamber development

reproductive structure development [inference]

gonad development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

wing disc pattern formation [inference]

wing disc anterior/posterior pattern formation

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

imaginal disc lineage restriction [inference]

anterior/posterior lineage restriction, imaginal disc

developmental process [inference]

developmental process involved in reproduction [inference]

follicle cell of egg chamber development

reproductive structure development [inference]

gonad development

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

animal organ morphogenesis [inference]

imaginal disc morphogenesis [inference]

eye-antennal disc morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

Bolwig's organ morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

animal organ development [inference]

gonad development

reproductive structure development [inference]

gonad development

cellular developmental process [inference]

cell fate commitment [inference]

determination of imaginal disc primordium [inference]

determination of genital disc primordium

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of epithelial cell migration, open tracheal system

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of epithelial cell migration, open tracheal system

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of epithelial cell migration, open tracheal system

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome
plasma membrane	IDA	PMID PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
cilium	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basal plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
smoothened binding	IBA	GO_REF
hedgehog receptor activity	IMP	PMID
hedgehog receptor activity	IBA	GO_REF
hedgehog receptor activity	IEA	GO_REF
lipoprotein particle receptor activity	IDA	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

smoothened binding

hedgehog family protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidic acid binding

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-4-phosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

cargo receptor activity [inference]

lipoprotein particle receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

hedgehog receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDRDSLPRVPDTHGDVVDEKLFSDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTTPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVELAMPGRAVRSYNFTS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
142	N-linked (GlcNAc...) asparagine	UniProt
298	N-linked (GlcNAc...) asparagine	UniProt
335	N-linked (GlcNAc...) asparagine	UniProt
388	N-linked (GlcNAc...) asparagine	UniProt
807	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Assembly of the 'signalling complexes'	Drosophila melanogaster
Hedgehog 'off' state	Drosophila melanogaster
Hedgehog 'on' state	Drosophila melanogaster
Ligand-receptor interactions	Drosophila melanogaster

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1289	neurodegenerative disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements