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Prothrombin
Summary
- UniProt ID
- P19221
- Gene Symbol
- F2 Cf2
- Gene ID
- 14061
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003459
- GlyGen
- P19221
- PubChem
- P19221
- Re-Glyco
- P19221
Annotation
- Keyword
- 3D-structure Acute phase Blood coagulation Calcium Cleavage on pair of basic residues Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Kringle Reference proteome Repeat Serine protease Signal Zymogen
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| proteolysis | ||
| proteolysis | ||
| acute-phase response |
|
|
| cell surface receptor signaling pathway | ||
| cell surface receptor signaling pathway |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of transmembrane transport [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| obsolete extracellular space |
|
|
| external side of plasma membrane | ||
| external side of plasma membrane | ||
| extracellular matrix | ||
| extracellular matrix |
| GO Term | Evidence Code | Reference |
|---|---|---|
| lipopolysaccharide binding | ||
| lipopolysaccharide binding | ||
| endopeptidase activity | ||
| serine-type endopeptidase activity | ||
| serine-type endopeptidase activity |
GO Hierarchy
Sequence
MSHVRGLGLPGCLALAALVSLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGVNYLGTVNVTHTGIQCQLWRSRYPHKPEINSTTHPGADLKENFCRNPDSSTTGPWCYTTDPTVRREECSVPVCGQEGRTTVVMTPRSGGSKDNLSPPLGQCLTERGRLYQGNLAVTTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVENFCRNPDWDEEGAWCYVAGQPGDFEYCNLNYCEEAVGEENYDVDESIAGRTTDAEFHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQKVIDQFG
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 122 |
|
|
||
| 144 |
|
|||
| 413 |
|
|||
| 553 |
|
G24748EV
G31986NC
G79652WX
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Amplification and propagation of coagulation cascade | Mus musculus |
| Cell surface interactions at the vascular wall | Mus musculus |
| Fibrin formation | Mus musculus |
| G alpha (q) signalling events | Mus musculus |
| Gamma-carboxylation of protein precursors | Mus musculus |
| Initiation of coagulation cascade | Mus musculus |
| Peptide ligand-binding receptors | Mus musculus |
| Platelet Aggregation (Plug Formation) | Mus musculus |
| Regulation of Complement cascade | Mus musculus |
| Regulation of clotting cascade | Mus musculus |
