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MIRAGE
Glutamate receptor 1
Summary
- UniProt ID
- P19490
- Gene Symbol
- GluA1 Glur1 Gria1
- Gene ID
- 50592
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- 3D-structure Alternative splicing Cell membrane Cell projection Disulfide bond Endoplasmic reticulum Endosome Glycoprotein Ligand-gated ion channel Palmitate Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| regulation of receptor recycling | ||
| regulation of receptor recycling | ||
| chemical synaptic transmission | ||
| synapse assembly | ||
| long-term memory |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| early endosome | ||
| endoplasmic reticulum | ||
| endoplasmic reticulum membrane | ||
| endoplasmic reticulum membrane | ||
| cytosol |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| amyloid-beta binding | ||
| amyloid-beta binding | ||
| G-protein alpha-subunit binding | ||
| glutamate-gated receptor activity | ||
| glutamate-gated receptor activity |
GO Hierarchy
molecular function
transporter activity [inference]
binding [inference]
Sequence
MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 63 |
|
|
||
| 249 |
|
|
||
| 257 |
|
|
||
| 363 |
|
|
||
| 401 |
|
|
||
| 406 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of AMPA receptors | Rattus norvegicus |
| COPII-mediated vesicle transport | Rattus norvegicus |
| Cargo concentration in the ER | Rattus norvegicus |
| Synaptic adhesion-like molecules | Rattus norvegicus |
| Trafficking of AMPA receptors | Rattus norvegicus |
| Trafficking of GluR2-containing AMPA receptors | Rattus norvegicus |
| Unblocking of NMDA receptors, glutamate binding and activation | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9975 | cocaine dependence | |
| DOID:9279 | hyperhomocysteinemia | |
| DOID:2560 | morphine dependence | |
| DOID:0060001 | withdrawal disorder |
