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Glutamate receptor 2

Summary

UniProt ID: P19491
Gene Symbol: GluA2 Glur2 Gria2
Gene ID: 29627
Organism: Rattus norvegicus (Norway rat)

External Links

GlyGen: P19491
PubChem: P19491
Re-Glyco: P19491

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Ligand-gated ion channel Palmitate Phosphoprotein Postsynaptic cell membrane RNA editing Receptor Reference proteome Signal Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	Reference
regulation of receptor recycling	IMP	PMID
regulation of receptor recycling	IEA	GO_REF
chemical synaptic transmission	ISO	GO_REF
chemical synaptic transmission	IDA	PMID
response to lithium ion	IEP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to glycine

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to glycine [inference]

cellular response to glycine

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

response to toxic substance [inference]

response to fungicide

response to metal ion [inference]

response to lithium ion

response to antibiotic [inference]

response to fungicide

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to glycine

response to nitrogen compound [inference]

response to amine [inference]

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

response to glycine [inference]

cellular response to glycine

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to glycine

response to glycine [inference]

cellular response to glycine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to glycine

cellular response to nitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to glycine

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

establishment of protein localization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

glutamate receptor clustering [inference]

AMPA glutamate receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of receptor recycling

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

positive regulation of synaptic transmission

long-term synaptic potentiation

regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission

long-term synaptic potentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

positive regulation of synaptic transmission

long-term synaptic potentiation

regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of metabolic process [inference]

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission

long-term synaptic potentiation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of synaptic plasticity [inference]

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GO Term	Evidence Code	Reference
endoplasmic reticulum	ISO	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	TAS	Reactome
plasma membrane	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

AMPA glutamate receptor complex

cellular anatomical structure [inference]

cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

dendritic spine cytoplasm

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

neuron to neuron synapse [inference]

asymmetric synapse

spine synapse

site of polarized growth [inference]

growth cone

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

somatodendritic compartment

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

presynapse

terminal bouton

postsynapse [inference]

dendritic spine

perisynaptic space

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	Reference
SNARE binding	IPI	PMID
amyloid-beta binding	IPI	PMID
amyloid-beta binding	IEA	GO_REF
glutamate-gated receptor activity	ISO	GO_REF
glutamate-gated receptor activity	TAS	PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glutamate-gated ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glutamate-gated ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glutamate-gated ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

carboxylic acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

binding [inference]

protein binding [inference]

SNARE binding

signaling receptor binding [inference]

glutamate receptor binding

ionotropic glutamate receptor binding

cytoskeletal protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

PDZ domain binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding

immunoglobulin binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	Source
256	N-linked (GlcNAc...) asparagine	21317873	UniProt GlyGen
370	N-linked (GlcNAc...) asparagine	19946266 21317873 25103405	UniProt GlyGen
406	N-linked (GlcNAc...) asparagine		UniProt GlyGen
413	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Activation of AMPA receptors	Rattus norvegicus
Trafficking of GluR2-containing AMPA receptors	Rattus norvegicus
Unblocking of NMDA receptors, glutamate binding and activation	Rattus norvegicus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9975	cocaine dependence	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements