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Thymidine phosphorylase

Summary

UniProt ID

P19971

Gene Symbol

ECGF1
TYMP

Gene ID

1890

Organism

Homo sapiens (human)

External Links

PubChem: P19971
The Human Metabolome Database: HMDBP03818
The O-GlcNAc Database: P19971
RaftProt: P19971
Re-Glyco: P19971

Annotation

Keyword: 3D-structure Alternative splicing Angiogenesis Chemotaxis Developmental protein Differentiation Direct protein sequencing Disease variant Glycosyltransferase Growth factor Neuropathy Phosphoprotein Progressive external ophthalmoplegia Proteomics identification Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	Reference
angiogenesis
pyrimidine nucleobase metabolic process	IEA	GO_REF
pyrimidine nucleoside metabolic process	IDA	PMID
pyrimidine nucleoside metabolic process	IMP	PMID
pyrimidine nucleoside metabolic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine nucleoside monophosphate metabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleoside monophosphate metabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine nucleoside monophosphate metabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleoside monophosphate metabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

organophosphate catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

organophosphate catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

carbohydrate derivative catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine nucleoside monophosphate metabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleoside monophosphate metabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process

nucleoside metabolic process [inference]

pyrimidine nucleoside metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine nucleoside monophosphate metabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleoside monophosphate metabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside monophosphate catabolic process [inference]

pyrimidine nucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

deoxyribonucleoside monophosphate catabolic process [inference]

pyrimidine deoxyribonucleoside monophosphate catabolic process [inference]

dTMP catabolic process

nucleotide catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process

nucleoside metabolic process [inference]

pyrimidine nucleoside metabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleotide metabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleotide catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

carbohydrate derivative metabolic process [inference]

nucleoside metabolic process [inference]

pyrimidine nucleoside metabolic process

2'-deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide metabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

dTMP metabolic process [inference]

dTMP catabolic process

carbohydrate derivative catabolic process [inference]

deoxyribose phosphate catabolic process [inference]

pyrimidine deoxyribonucleotide catabolic process [inference]

dTMP catabolic process

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation

locomotion [inference]

taxis [inference]

chemotaxis

Displaying **all 2** entries
GO Term	Evidence Code	Reference
cytosol	TAS	Reactome Reactome
cytosol	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
1,4-alpha-oligoglucan phosphorylase activity	IEA	GO_REF
growth factor activity
thymidine phosphorylase activity	IDA	PMID
thymidine phosphorylase activity	IMP	PMID
thymidine phosphorylase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

1,4-alpha-oligoglucan phosphorylase activity

pentosyltransferase activity [inference]

pyrimidine-nucleoside phosphorylase activity [inference]

thymidine phosphorylase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
65		23576270 38253038 40596516 40914422	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Pyrimidine catabolism	Homo sapiens
Pyrimidine salvage	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080119	mitochondrial DNA depletion syndrome 1	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2671	transitional cell carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:890	mitochondrial encephalomyopathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements