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Thioredoxin-dependent peroxide reductase, mitochondrial

Summary

UniProt ID: P20108
Gene Symbol: Aop1 Mer5 Prdx3
Gene ID: 11757
Organism: Mus musculus (house mouse)

External Links

GlyGen: P20108
O-GlcNAcAtlas: P20108
Re-Glyco: P20108

Annotation

Keyword: Acetylation Antioxidant Cytoplasm Direct protein sequencing Disulfide bond Endosome Mitochondrion Palmitate Peroxidase Phosphoprotein Redox-active center Reference proteome Transit peptide

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
maternal placenta development	IMP	PMID
response to oxidative stress	ISO	GO_REF
response to oxidative stress	IMP	PMID PMID
response to oxidative stress	IBA	GO_REF
response to oxidative stress	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

reproductive process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy [inference]

maternal placenta development

developmental process [inference]

developmental process involved in reproduction [inference]

maternal placenta development

anatomical structure development [inference]

maternal placenta development

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to reactive oxygen species [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

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GO Term	Evidence Code	Reference
nucleoplasm	ISO	GO_REF
cytoplasm	ISS	GO_REF
cytoplasm	ISO	GO_REF
cytoplasm	IEA	GO_REF GO_REF
mitochondrion	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

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GO Term	Evidence Code	Reference
thioredoxin peroxidase activity	ISO	GO_REF
thioredoxin peroxidase activity	IBA	GO_REF
thioredoxin peroxidase activity	IEA	GO_REF
protein kinase binding	ISO	GO_REF
protein kinase binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

antioxidant activity [inference]

peroxidase activity [inference]

peroxiredoxin activity [inference]

thioredoxin-dependent peroxiredoxin activity [inference]

thioredoxin peroxidase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

cysteine-type endopeptidase regulator activity involved in apoptotic process [inference]

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAAAAGRLLWSSVARHASAISRSISASTVLRPVASRRTCLTDILWSASAQGKSAFSTSSSFHTPAVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDITKQISRDYGVLLESAGIALRGLFIIDPNGVVKHLSVNDLPVGRSVEETLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites