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Neurotrophin-3
Summary
- UniProt ID
- P20181
- Gene Symbol
- Ntf3 Ntf-3
- Gene ID
- 18205
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
- Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| positive regulation of receptor internalization | ||
| cell surface receptor protein tyrosine kinase signaling pathway | ||
| cell surface receptor protein tyrosine kinase signaling pathway | ||
| neuromuscular synaptic transmission | ||
| nervous system development |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| obsolete extracellular space |
|
|
| endoplasmic reticulum lumen | ||
| endoplasmic reticulum lumen |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| nerve growth factor receptor binding | ||
| neurotrophin p75 receptor binding | ||
| growth factor activity | ||
| growth factor activity | ||
| chemoattractant activity |
GO Hierarchy
Sequence
MSILFYVIFLAYLRGIQGNSMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPEQGEATRSEFQPMIATDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGNPVVANRTSPRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 131 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NTRK3 signals through PI3K | Mus musculus |
| Activated NTRK3 signals through PLCG1 | Mus musculus |
| NTF3 activates NTRK3 signaling | Mus musculus |
| PI3K/AKT Signaling | Mus musculus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:6419 | tetralogy of Fallot | |
| DOID:0110106 | atrial heart septal defect 1 |
