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Neuroglian

Summary

UniProt ID: P20241
Gene Symbol: CG1634 Nrg
Gene ID: 31792
Organism: Drosophila melanogaster (fruit fly)

External Links

GlyGen: P20241
Re-Glyco: P20241

Annotation

Keyword: 3D-structure Alternative splicing Cell adhesion Cell junction Cell membrane Developmental protein Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
neuron cell-cell adhesion	IMP	PMID
axonogenesis	IMP	PMID
imaginal disc morphogenesis	IMP	PMID
motor neuron axon guidance	IMP	PMID
male courtship behavior	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

encapsulation of foreign target [inference]

melanotic encapsulation of foreign target

immune response [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cellular process [inference]

cell adhesion [inference]

cell adhesion involved in heart morphogenesis

cell-cell adhesion

neuron cell-cell adhesion

ensheathment of neurons [inference]

axon ensheathment

metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

secondary metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

pigment metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

tight junction organization [inference]

tight junction assembly [inference]

septate junction assembly

synapse organization

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

courtship behavior [inference]

male mating behavior [inference]

male courtship behavior

female mating behavior [inference]

multicellular organismal process [inference]

behavior [inference]

reproductive behavior [inference]

mating behavior [inference]

courtship behavior [inference]

male mating behavior [inference]

male courtship behavior

female mating behavior [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

imaginal disc morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

nerve maturation

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

establishment of glial blood-brain barrier

establishment of blood-brain barrier [inference]

establishment of glial blood-brain barrier

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

immune response [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

biological regulation [inference]

regulation of biological quality [inference]

regulation of tube architecture, open tracheal system [inference]

regulation of tube size, open tracheal system

regulation of female receptivity

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube size, open tracheal system

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
plasma membrane	EXP	PMID
plasma membrane	IDA	PMID PMID PMID
plasma membrane	IEA	GO_REF
plasma membrane	HDA	PMID
septate junction	IDA	PMID PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

lateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

septate junction

pleated septate junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

actin-based cell projection [inference]

filopodium

cell body [inference]

neuronal cell body

Displaying **all 2** entries
GO Term	Evidence Code	Reference
calcium ion binding	IDA	PMID
cell adhesion molecule binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cell adhesion molecule binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWRQSTILAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGFHEYSQPLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTGQFTEDGSFIGQYVPGKLQPPVSPQPLNNSAAAHQAAPTAGGSGAAGSAAAAGASGGASSAGGAAASNGGAAAGAVATYV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	PubMed ID	Source
182	N-linked (GlcNAc...) asparagine		UniProt GlyGen
198	N-linked (GlcNAc...) asparagine	17893096	UniProt GlyGen
411	N-linked (GlcNAc...) asparagine	17893096 19349973	UniProt GlyGen
448	N-linked (GlcNAc...) asparagine		UniProt GlyGen
652	N-linked (GlcNAc...) asparagine	7512815	UniProt GlyGen
683	N-linked (GlcNAc...) asparagine	7512815	UniProt GlyGen
821	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1024			GlyGen
1125	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 13 in total

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Pathway Name	Organism
Degradation of the extracellular matrix	Drosophila melanogaster
ECM proteoglycans	Drosophila melanogaster
Formation of the dystrophin-glycoprotein complex (DGC)	Drosophila melanogaster
Glycosaminoglycan-protein linkage region biosynthesis	Drosophila melanogaster
HS-GAG biosynthesis	Drosophila melanogaster
HS-GAG degradation	Drosophila melanogaster
Integrin cell surface interactions	Drosophila melanogaster
NCAM signaling for neurite out-growth	Drosophila melanogaster
NCAM1 interactions	Drosophila melanogaster
Non-integrin membrane-ECM interactions	Drosophila melanogaster

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060246	MASA syndrome	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements