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Lamin-B1

Summary

UniProt ID

P20700

Gene Symbol

LMN2
LMNB
LMNB1

Gene ID

[4001]

Organism

Homo sapiens (human)

External Links

GlyGen: P20700
PubChem: P20700
The O-GlcNAc Database: P20700
RaftProt: P20700
O-GlcNAcAtlas: P20700
Re-Glyco: P20700

Annotation

Keyword: 3D-structure Acetylation Chromosomal rearrangement Coiled coil Direct protein sequencing Disease variant Disulfide bond Glycoprotein Intellectual disability Intermediate filament Isopeptide bond Leukodystrophy Methylation Nucleus Phosphoprotein Prenylation Primary microcephaly Proteomics identification Reference proteome Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
nuclear envelope organization	IMP	PMID
nuclear envelope organization	IBA	GO_REF
nuclear envelope organization	IEA	GO_REF
nuclear migration	IBA	GO_REF
heterochromatin formation	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

nuclear migration

localization within membrane [inference]

nuclear pore localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

heterochromatin organization [inference]

heterochromatin formation

organelle organization [inference]

nucleus organization [inference]

nuclear pore localization

cellular component assembly [inference]

heterochromatin formation

membrane organization [inference]

nuclear envelope organization

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein localization to nuclear envelope

protein-containing complex localization [inference]

nuclear pore localization

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

organelle localization [inference]

nucleus localization [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

localization within membrane [inference]

nuclear pore localization

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
nucleus	IDA	PMID
nucleus	IEA	GO_REF
nuclear envelope	TAS	Reactome
nuclear envelope	IDA	PMID
nuclear envelope	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane

nuclear inner membrane

nuclear matrix

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament [inference]

lamin filament

Displaying **all 5** entries
GO Term	Evidence Code	Reference
structural constituent of cytoskeleton	IBA	GO_REF
phospholipase binding	IEA	GO_REF
structural constituent of nuclear lamina	TAS	PMID
structural constituent of nuclear lamina	IEA	GO_REF
sequence-specific double-stranded DNA binding	IEA	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding

protein binding [inference]

enzyme binding [inference]

phospholipase binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
19				GlyGen
28		22121020 22967762 28411811 28510447 29351928 30379171 30444036 32119511 32522876 33214551 34019948 34725712 38665916 39894887 40596516 40914422	G49108TO G70994MS	GlyGen The O-GlcNAc Database
282			G99902UR	GlyGen
399	O-linked (GlcNAc) threonine	26237509 28939839		UniProt GlyGen
401		22121020 22967762 28411811 28510447 29351928 30379171 30444036 32119511 32522876 33214551 34019948 34725712 38665916 39894887 40596516 40914422	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
Breakdown of the nuclear lamina	Homo sapiens
Depolymerization of the Nuclear Lamina	Homo sapiens
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Homo sapiens
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Homo sapiens
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Homo sapiens
Initiation of Nuclear Envelope (NE) Reformation	Homo sapiens
Meiotic synapsis	Homo sapiens
Nuclear Envelope Breakdown	Homo sapiens
RHOD GTPase cycle	Homo sapiens
RHOF GTPase cycle	Homo sapiens

Human Protein Atlas

ENSG00000113368

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060785	typical adult-onset autosomal dominant demyelinating leukodystrophy	Alliance of Genome Resources
DOID:0070296	autosomal recessive primary microcephaly	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements