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Glycine receptor subunit beta

Summary

UniProt ID: P20781
Gene Symbol: Glrb
Gene ID: 25456
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: P20781
Re-Glyco: P20781

Annotation

Keyword: 3D-structure Cell membrane Cell projection Chloride channel Cytoplasm Direct protein sequencing Disulfide bond Glycoprotein Ligand-gated ion channel Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
startle response	ISS	PMID
startle response	ISO	GO_REF
startle response	IEA	GO_REF
monoatomic ion transport	ISS	PMID
ion transport	ISS	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glycinergic

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

acrosome reaction

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

neuromuscular process

startle response

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to external stimulus [inference]

startle response

reflex [inference]

righting reflex

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glycinergic

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of biological quality [inference]

regulation of membrane potential

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GO Term	Evidence Code	Reference
cytoplasm	ISO	GO_REF
cytoplasm	EXP	PMID
cytoplasm	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

glycine-gated chloride channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex [inference]

glycine-gated chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex [inference]

glycine-gated chloride channel complex

cellular anatomical structure [inference]

cytoplasm

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

postsynaptic specialization

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GO Term	Evidence Code	Reference
transmembrane signaling receptor activity	IEA	GO_REF
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA	GO_REF
glycine binding	ISS	PMID
glycine binding	ISO	GO_REF
glycine binding	IDA	PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

binding [inference]

amino acid binding [inference]

glycine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

glycine binding

cation binding [inference]

glycine binding

organic acid binding [inference]

carboxylic acid binding [inference]

glycine binding

protein-containing complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites