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Cytochrome P450 3A5

Summary

UniProt ID: P20815
Gene Symbol: CYP3A5
Gene ID: 1577
Organism: Homo sapiens (human)

External Links

GlyGen

P20815

PubChem

P20815

SwissLipids

SLP:000001325

The Human Metabolome Database

HMDBP01554

The O-GlcNAc Database

P20815

O-GlcNAcAtlas

P20815

Re-Glyco

P20815

Annotation

Keyword: 3D-structure Alternative splicing Heme Membrane Microsome Monooxygenase Proteomics identification Reference proteome Steroid metabolism

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
lipid hydroxylation	IDA	PMID
lipid hydroxylation	IEA	GO_REF
xenobiotic metabolic process	TAS	Reactome
steroid metabolic process	TAS	PMID
steroid metabolic process	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

xenobiotic catabolic process

catabolic process [inference]

alkaloid metabolic process [inference]

alkaloid catabolic process

secondary metabolic process [inference]

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

hormone metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

steroid metabolic process

estrogen metabolic process

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

demethylation [inference]

oxidative demethylation

olefinic compound metabolic process [inference]

retinol metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 3** entries
GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	TAS	Reactome Reactome Reactome
endoplasmic reticulum membrane	IEA	GO_REF GO_REF
intracellular membrane-bounded organelle	TAS	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
monooxygenase activity	ISS	GO_REF
monooxygenase activity	TAS	PMID Reactome Reactome Reactome
monooxygenase activity	IEA	GO_REF
iron ion binding	IEA	GO_REF
retinoic acid 4-hydroxylase activity	IDA	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity [inference]

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

binding [inference]

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
42				GlyGen
278		36240223 39894887	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Aflatoxin activation and detoxification	Homo sapiens
Xenobiotics	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080630	B-lymphoblastic leukemia/lymphoma	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:8552	chronic myeloid leukemia	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements