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ATP-dependent translocase ABCB1

Summary

UniProt ID: P21448
Gene Symbol: ABCB1 PGP1 PGY1
Gene ID: 100682536
Organism: Cricetulus griseus (Chinese hamster)

External Links

Re-Glyco: P21448

Annotation

Keyword: 3D-structure ATP-binding Cell membrane Cytoplasm Glycoprotein Lipid transport Phosphoprotein Reference proteome Repeat Translocase Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
epidermal growth factor receptor signaling pathway
adult heart development
female gonad development
response to xenobiotic stimulus
gene expression

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process

intercellular transport [inference]

oligopeptide export from mitochondrion

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

transmembrane transport [inference]

oligopeptide transmembrane transport [inference]

oligopeptide export from mitochondrion

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

lipid export from cell [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

behavior [inference]

exploration behavior

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure development [inference]

regeneration [inference]

tissue regeneration [inference]

neural tissue regeneration

animal organ development [inference]

heart development [inference]

adult heart development

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

neural tissue regeneration

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

lipid translocation [inference]

phospholipid translocation

isoprenoid transport [inference]

terpenoid transport

lipid export from cell [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

intercellular transport [inference]

oligopeptide export from mitochondrion

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

peptide transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

oligopeptide export from mitochondrion

organic hydroxy compound transport [inference]

aldosterone secretion

xenobiotic transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

secretion [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

transmembrane transport [inference]

oligopeptide transmembrane transport [inference]

oligopeptide export from mitochondrion

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

nitrogen compound transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

oligopeptide export from mitochondrion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

lipid export from cell [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

corticosteroid hormone secretion [inference]

mineralocorticoid secretion [inference]

aldosterone secretion

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
cytoplasm	ISS	GO_REF
cytoplasm	IEA	GO_REF
mitochondrial inner membrane	IEA	GO_REF
apical plasma membrane	ISS	GO_REF
apical plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
ATP binding	IEA	GO_REF
ABC-type xenobiotic transporter activity	ISS	GO_REF
ABC-type xenobiotic transporter activity	IEA	GO_REF
ABC-type oligopeptide transporter activity	IEA	GO_REF
efflux transmembrane transporter activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

oligopeptide transmembrane transporter activity [inference]

ABC-type oligopeptide transporter activity

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

intramembrane lipid carrier activity [inference]

phosphatidylcholine intramembrane carrier activity [inference]

phosphatidylcholine floppase activity

sphingolipid intramembrane carrier activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

ATPase-coupled intramembrane lipid carrier activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular carrier activity [inference]

lipid carrier activity [inference]

intramembrane lipid carrier activity [inference]

phosphatidylcholine intramembrane carrier activity [inference]

phosphatidylcholine floppase activity

sphingolipid intramembrane carrier activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

ATPase-coupled intramembrane lipid carrier activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ATPase-coupled intramembrane lipid carrier activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEFEEDFSGRKDKNFLKMGRKSKKEKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFASVGNIPTNATNNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGESKNEIDNLDMSSKDSASSLIRRRSTRRSIRGPHDQDRKLSTKEALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
87	N-linked (GlcNAc...) asparagine	UniProt
91	N-linked (GlcNAc...) asparagine	UniProt
96	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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