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Biglycan

Summary

UniProt ID

P21809

Gene Symbol

Gene ID

280733

Organism

Bos taurus (domestic cattle)

External Links

PubChem: P21809
Re-Glyco: P21809

Annotation

Keyword: 3D-structure Direct protein sequencing Disulfide bond Extracellular matrix Leucine-rich repeat Proteoglycan Reference proteome Repeat Signal

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	Reference
bone development
articular cartilage development

GO Hierarchy

biological process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cartilage development [inference]

articular cartilage development

bone development

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome
extracellular region	IEA	GO_REF
obsolete extracellular space
cell surface	IEA	GO_REF
transport vesicle	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane [inference]

sarcolemma

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

Displaying **all 3** entries
GO Term	Evidence Code	Reference
glycosaminoglycan binding	IEA	GO_REF
cytokine binding	IEA	GO_REF
extracellular matrix binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWPLWPLAALLALSQALPFEQKAFWDFTLDDGLPMLNDEEASGAETTSGIPDLDSLPPTYSAMCPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNITKVGVNDFCPVGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYKK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	Source
42	O-linked (Xyl...) (glycosaminoglycan) serine	2656687 2914936	UniProt
48	O-linked (Xyl...) (glycosaminoglycan) serine	2656687 2914936	UniProt
181	O-linked (Xyl...) (glycosaminoglycan) serine		UniProt
199	O-linked (Xyl...) (glycosaminoglycan) serine		UniProt
271	N-linked (GlcNAc...) asparagine		UniProt
312	N-linked (GlcNAc...) asparagine	16547006	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
A tetrasaccharide linker sequence is required for GAG synthesis	Bos taurus
CS/DS degradation	Bos taurus
Chondroitin sulfate biosynthesis	Bos taurus
Dermatan sulfate biosynthesis	Bos taurus
ECM proteoglycans	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements