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Lactadherin

Summary

UniProt ID

P21956

Gene Symbol

Mfge8

Gene ID

[17304]

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003484

GlyConnect

Lactadherin

GlyGen

P21956

PubChem

P21956

The O-GlcNAc Database

P21956

RaftProt

P21956

Re-Glyco

P21956

Annotation

Keyword: 3D-structure Alternative splicing Angiogenesis Cell adhesion Cytoplasmic vesicle Direct protein sequencing Disulfide bond EGF-like domain Fertilization Glycoprotein Membrane Reference proteome Repeat Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
angiogenesis
phagocytosis, recognition	IDA	PMID
phagocytosis, engulfment	IDA	PMID
cell adhesion
single fertilization

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell recognition [inference]

phagocytosis, recognition

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

reproductive process [inference]

fertilization [inference]

single fertilization

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

import into cell [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

Displaying **all 4** entries
GO Term	Evidence Code	Reference
acrosomal membrane	IEA	GO_REF
obsolete extracellular space
external side of plasma membrane	IDA	PMID
extracellular matrix	HDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

external encapsulating structure [inference]

extracellular matrix

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
phosphatidylserine binding	ISO	GO_REF
phosphatidylserine binding	IDA	PMID
phosphatidylserine binding	IBA	GO_REF
phosphatidylserine binding	IEA	GO_REF
integrin binding	IDA	PMID PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

lipid binding [inference]

phospholipid binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylserine binding

protein-containing complex binding [inference]

integrin binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MQVSRVLAALCGMLLCASGLFAASGDFCDSSLCLNGGTCLTGQDNDIYCLCPEGFTGLVCNETERGPCSPNPCYNDAKCLVTLDTQRGDIFTEYICQCPVGYSGIHCETETNYYNLDGEYMFTTAVPNTAVPTPAPTPDLSNNLASRCSTQLGMEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRKFEFIQDESGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQMSASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLGC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
61	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
133		34887587 39950214	G49108TO	GlyGen The O-GlcNAc Database
137				GlyGen
266	N-linked (GlcNAc...) asparagine	30899004	G70101JE G80920RR	GlycoProtDB UniProt GlyGen GlyConnect
316	N-linked (GlcNAc...) asparagine	30899004	G48584BU G80920RR	GlycoProtDB UniProt GlyGen GlyConnect
426	N-linked (GlcNAc...) asparagine			UniProt GlyGen