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Interleukin-6 receptor subunit alpha

Summary

UniProt ID

P22272

Gene Symbol

Il6r
Il6ra

Gene ID

16194

Organism

Mus musculus (house mouse)

External Links

PubChem: P22272
Re-Glyco: P22272

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
extracellular region
plasma membrane
interleukin-6 receptor complex
ciliary neurotrophic factor receptor complex
cell surface
apical plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 10** entries
GO Term
positive regulation of interleukin-6 production
vascular endothelial growth factor production
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
interleukin-6-mediated signaling pathway
T-helper 17 cell lineage commitment
positive regulation of chemokine production
endocrine pancreas development
positive regulation of glomerular mesangial cell proliferation
receptor signaling pathway via STAT

Displaying **all 7** entries
GO Term
protein homodimerization activity
ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-6 receptor binding
interleukin-6 binding
ciliary neurotrophic factor binding
enzyme binding

Annotation information from UniProt.

Sequence

MLTVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNVTIHWVYSGSQNREWTTTGNTLVLRDVQLSDTGDYLCSLNDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAICEWRPSSTPSPTTKAVLFAKKINTTNGKSDFQVPCQYSQQLKSFSCQVEILEGDKVYHIVSLCVANSVGSKSSHNEAFHSLKMVQPDPPANLVVSAIPGRPRWLKVSWQHPETWDPSYYLLQFQLRYRPVWSKEFTVLLLPVAQYQCVIHDALRGVKHVVQVRGKEELDLGQWSEWSPEVTGTPWIAEPRTTPAGILWNPTQVSVEDSANHEDQYESSTEATSVLAPVQESSSMSLPTFLVAGGSLAFGLLLCVFIILRLKQKWKSEAEKESKTTSPPPPPYSLGPLKPTFLLVPLLTPHSSGSDNTVNHSCLGVRDAQSPYDNSNRDYLFPR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
32	N-linked (GlcNAc...) asparagine	UniProt
55	N-linked (GlcNAc...) asparagine	UniProt
150	N-linked (GlcNAc...) asparagine	UniProt
218	N-linked (GlcNAc...) asparagine	UniProt