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MIRAGE
Fibroblast growth factor receptor 4

Summary
UniProt ID
P22455
Gene Symbol
  • FGFR4
  • JTK2
  • TKF
Gene ID
2264
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011610
GlyConnect
GlyGen
P22455
PubChem
P22455
The Human Metabolome Database
HMDBP01234
Re-Glyco
P22455
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Endoplasmic reticulum
  • Endosome
  • Glycoprotein
  • Immunoglobulin domain
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane helix
  • Tyrosine-protein kinase
  • Ubl conjugation
Gene Ontology (GO)
Displaying all 7 entries
GO Term
extracellular region
plasma membrane
receptor complex
endosome
endoplasmic reticulum
Golgi apparatus
transport vesicle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 8 entries
Position Description PubMed ID GlyTouCan ID Source
112 N-linked (GlcNAc...) asparagine
177
258 N-linked (GlcNAc...) asparagine
260
290 N-linked (GlcNAc...) asparagine
311 N-linked (GlcNAc...) asparagine
322 N-linked (GlcNAc...) asparagine
508
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 14 in total
Pathway Name Organism
Constitutive Signaling by Aberrant PI3K in Cancer Homo sapiens
FGFR4 ligand binding and activation Homo sapiens
FGFR4 mutant receptor activation Homo sapiens
FRS-mediated FGFR4 signaling Homo sapiens
Negative regulation of FGFR4 signaling Homo sapiens
PI-3K cascade:FGFR4 Homo sapiens
PI3K Cascade Homo sapiens
PI3K/AKT Signaling Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Homo sapiens
Phospholipase C-mediated cascade; FGFR4 Homo sapiens
Disease
Displaying all 9 entries
DO ID Disease Name Source
DOID:0050866 oral squamous cell carcinoma
DOID:10283 prostate cancer
DOID:10534 stomach cancer
DOID:3748 esophagus squamous cell carcinoma
DOID:3907 lung squamous cell carcinoma
DOID:3908 lung non-small cell carcinoma
DOID:3910 lung adenocarcinoma
DOID:5082 liver cirrhosis
DOID:5520 head and neck squamous cell carcinoma
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025