Furin

Summary
UniProt ID
P23377
Gene Symbol
  • Furin
  • Fur
  • Pcsk3
Organism
Rattus norvegicus (Norway rat)
External Links
PubChem
P23377
Annotation
Keyword
  • Autocatalytic cleavage
  • Calcium
  • Cell membrane
  • Cleavage on pair of basic residues
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Golgi apparatus
  • Heparin-binding
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Transmembrane helix
  • Zymogen
Gene Ontology (GO)
Sequence
MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAVADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQRVPQVKWLEQQVAKQRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLSCLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
387 N-linked (GlcNAc...) asparagine
440 N-linked (GlcNAc...) asparagine
553 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 9 entries
Pathway Name Organism
Activation of Matrix Metalloproteinases Rattus norvegicus
Assembly of active LPL and LIPC lipase complexes Rattus norvegicus
Collagen degradation Rattus norvegicus
Elastic fibre formation Rattus norvegicus
NGF processing Rattus norvegicus
Removal of aminoterminal propeptides from gamma-carboxylated proteins Rattus norvegicus
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Rattus norvegicus
Signaling by PDGF Rattus norvegicus
TGF-beta receptor signaling activates SMADs Rattus norvegicus

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024