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Glycine receptor subunit alpha-1

Summary

UniProt ID

P23415

Gene Symbol

GLRA1

Gene ID

[2741]

Organism

Homo sapiens (human)

External Links

PubChem: P23415
The Human Metabolome Database: HMDBP08216
Re-Glyco: P23415

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Cell projection Chloride channel Disease variant Disulfide bond Glycoprotein Ligand-gated ion channel Metal-binding Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Signal Transmembrane helix Zinc

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
startle response	IMP	PMID PMID
regulation of respiratory gaseous exchange by nervous system process
ion transport	IDA	PMID
monoatomic ion transport	IDA	PMID
monoatomic ion transport	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

acrosome reaction

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

nervous system process [inference]

regulation of respiratory gaseous exchange by nervous system process

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

neuromuscular process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

response to stimulus [inference]

response to external stimulus [inference]

startle response

reflex [inference]

righting reflex

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

response to metal ion [inference]

response to zinc ion [inference]

cellular response to zinc ion

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

response to oxygen-containing compound [inference]

response to alcohol

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

positive regulation of biological process [inference]

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

regulation of multicellular organismal process [inference]

regulation of respiratory gaseous exchange [inference]

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of reproductive process [inference]

regulation of acrosome reaction [inference]

positive regulation of acrosome reaction

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

regulation of biological quality [inference]

regulation of membrane potential

action potential [inference]

neuronal action potential

regulation of postsynaptic membrane potential [inference]

inhibitory postsynaptic potential

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
plasma membrane	EXP	PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID
plasma membrane	TAS	Reactome
plasma membrane	IDA	PMID PMID PMID GO_REF
plasma membrane	IMP	PMID
plasma membrane	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
transmembrane signaling receptor activity	IEA	GO_REF
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA	GO_REF
zinc ion binding	IMP	PMID
glycine binding	IDA	PMID PMID PMID PMID
glycine binding	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

binding [inference]

protein binding [inference]

identical protein binding

amino acid binding [inference]

glycine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

glycine binding

alkanesulfonate binding [inference]

taurine binding

cation binding [inference]

glycine binding

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

glycine binding

alkanesulfonate binding [inference]

taurine binding

sulfur compound binding [inference]

alkanesulfonate binding [inference]

taurine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
66	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Neurotransmitter receptors and postsynaptic signal transmission	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060696	hyperekplexia 1	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements