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Tyrosine-protein kinase JAK1

Summary

UniProt ID

P23458

Gene Symbol

JAK1
JAK1A
JAK1B

Organism

Homo sapiens (human)

External Links

GlyConnect

1869

GlyGen

P23458

PubChem

P23458

The Human Metabolome Database

HMDBP01309

RaftProt

P23458

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Disease variant
Magnesium
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Repeat
SH2 domain
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 22 in total

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GO Term
protein phosphorylation
cytokine-mediated signaling pathway
cell differentiation
intracellular signal transduction
protein localization to cell-cell junction
positive regulation of protein localization to nucleus
growth hormone receptor signaling pathway via JAK-STAT
response to antibiotic
interleukin-4-mediated signaling pathway
interleukin-2-mediated signaling pathway

Displaying **all 9** entries
GO Term
nucleus
cytoplasm
cytoskeleton
plasma membrane
cytosol
endosome
focal adhesion
cytoplasmic side of plasma membrane
extrinsic component of cytoplasmic side of plasma membrane

Displaying **all 8** entries
GO Term
ubiquitin protein ligase binding
CCR5 chemokine receptor binding
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
ATP binding
protein phosphatase binding
protein tyrosine kinase activity
metal ion binding

Annotation information from UniProt.

Sequence

MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
769			G23294PN G82463GQ	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 20** of 29 in total

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Pathway Name	Organism
Interleukin-15 signaling	Homo sapiens
Interleukin-2 signaling	Homo sapiens
Interleukin-20 family signaling	Homo sapiens
Interleukin-21 signaling	Homo sapiens
Interleukin-27 signaling	Homo sapiens
Interleukin-35 Signalling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens
Interleukin-6 signaling	Homo sapiens
Interleukin-7 signaling	Homo sapiens
Interleukin-9 signaling	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements