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Alpha-crystallin B chain

Summary

UniProt ID

P23927

Gene Symbol

Crya2
Cryab

Gene ID

12955

Organism

Mus musculus (house mouse)

External Links

GlyGen: P23927
PubChem: P23927
The O-GlcNAc Database: P23927
RaftProt: P23927
O-GlcNAcAtlas: P23927
Re-Glyco: P23927

Annotation

Keyword: Acetylation Chaperone Cytoplasm Direct protein sequencing Eye lens protein Lysosome Metal-binding Methylation Nucleus Phosphoprotein Reference proteome Secreted Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 43 in total

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GO Term	Evidence Code	Reference
response to hypoxia	IMP	PMID
lens development in camera-type eye	IGI	PMID
protein folding	ISO	GO_REF
protein folding	IEA	GO_REF
glutathione metabolic process	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

protein folding

protein refolding

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization

signal transduction [inference]

intracellular signal transduction [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

intracellular signaling cassette [inference]

MAPK cascade [inference]

stress-activated MAPK cascade

metabolic process [inference]

modified amino acid metabolic process [inference]

glutathione metabolic process

sulfur compound metabolic process [inference]

glutathione metabolic process

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development [inference]

apoptotic process involved in morphogenesis

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization

cellular component assembly [inference]

protein-containing complex assembly [inference]

tubulin complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

tubulin complex assembly

developmental process [inference]

anatomical structure development [inference]

lens development in camera-type eye

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development

muscle organ development

muscle structure development [inference]

muscle organ development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to heat

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to radiation [inference]

response to ionizing radiation [inference]

response to gamma radiation [inference]

cellular response to gamma radiation

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

response to chemical [inference]

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to estradiol

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

negative regulation of transport [inference]

negative regulation of intracellular transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of reactive oxygen species metabolic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

negative regulation of transport [inference]

negative regulation of intracellular transport

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade

intracellular signaling cassette [inference]

MAPK cascade [inference]

stress-activated MAPK cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of reactive oxygen species metabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

regulation of programmed cell death

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of reactive oxygen species metabolic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	ISO	GO_REF
extracellular region	IEA	GO_REF
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

contractile muscle fiber

myofibril [inference]

cardiac myofibril

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular membraneless organelle [inference]

contractile muscle fiber

myofibril [inference]

cardiac myofibril

postsynapse [inference]

dendritic spine

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile muscle fiber

myofibril [inference]

cardiac myofibril

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
amyloid-beta binding	ISO	GO_REF
amyloid-beta binding	IEA	GO_REF
structural molecule activity	ISO	GO_REF
structural molecule activity	IEA	GO_REF
structural constituent of eye lens	TAS	PMID

GO Hierarchy

molecular function

structural molecule activity

structural constituent of eye lens

binding [inference]

protein binding [inference]

cytoskeletal protein binding

tubulin binding [inference]

microtubule binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

unfolded protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFSTATSLSPFYLRPPSFLRAPSWIDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVAAAPKK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
162		27301331 30016717 36288343 37507081 40021952	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
HSF1-dependent transactivation	Mus musculus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080093	adult-onset myofibrillar myopathy 2A	Alliance of Genome Resources
DOID:0110250	cataract 16 multiple types	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements