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MIRAGE
Insulin-like growth factor 1 receptor
Summary
- UniProt ID
- P24062
- Gene Symbol
- Igf1r
- Gene ID
- 25718
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- ATP-binding Cell membrane Cleavage on pair of basic residues Disulfide bond Glycoprotein Isopeptide bond Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Tyrosine-protein kinase Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| cardiac atrium development | ||
| immune response | ||
| axonogenesis | ||
| brain development | ||
| positive regulation of cell population proliferation |
GO Hierarchy
- immune response
- response to nicotine
biological process
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
response to hormone
response to lipid [inference]
cellular response to chemical stimulus [inference]
response to nitrogen compound [inference]
response to oxygen-containing compound [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| nucleolus |
|
|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| insulin receptor complex |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| G-protein alpha-subunit binding | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity |
GO Hierarchy
Sequence
MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMELELEPENMESVPLDPSASSASLPLPERHSGHKAENGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 51 |
|
|
||
| 102 |
|
|
||
| 135 |
|
|
||
| 245 |
|
|
||
| 314 |
|
|
||
| 418 |
|
|
||
| 439 |
|
|
||
| 535 |
|
|
||
| 608 |
|
|
||
| 623 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Extra-nuclear estrogen signaling | Rattus norvegicus |
| IRS-related events triggered by IGF1R | Rattus norvegicus |
| SHC-related events triggered by IGF1R | Rattus norvegicus |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14330 | Parkinson's disease | |
| DOID:10652 | Alzheimer's disease | |
| DOID:2526 | prostate adenocarcinoma |
