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Cathepsin D [Cleaved into: Cathepsin D 12 kDa light chain; Cathepsin D 9 kDa light chain; Cathepsin D 34 kDa heavy chain; Cathepsin D 30 kDa heavy chain]

Summary

UniProt ID

P24268

Gene Symbol

Ctsd

Gene ID

[""]

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P24268
PubChem: P24268
The O-GlcNAc Database: P24268
Re-Glyco: P24268

Annotation

Keyword: 3D-structure Aspartyl protease Direct protein sequencing Disulfide bond Glycoprotein Lysosome Reference proteome Secreted Signal Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
autophagosome assembly	ISO	GO_REF
proteolysis	ISO	GO_REF
proteolysis	IBA	GO_REF
proteolysis	IEA	GO_REF
protein catabolic process	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

receptor metabolic process [inference]

receptor recycling [inference]

insulin receptor recycling

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

vesicle-mediated transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

execution phase of apoptosis

response to stimulus [inference]

response to nutrient levels

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

synaptic vesicle endosomal processing

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

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GO Term	Evidence Code	Reference
obsolete extracellular space
lysosome	ISO	GO_REF
lysosome	IBA	GO_REF
lysosome	IEA	GO_REF GO_REF
lysosomal membrane	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse [inference]

GABA-ergic synapse

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

presynaptic endosome

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

presynaptic endosome

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

presynaptic endosome

pigment granule [inference]

melanosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
endopeptidase activity	ISO	GO_REF
endopeptidase activity	IDA	PMID PMID PMID
endopeptidase activity	IMP	PMID
endopeptidase activity	IEA	GO_REF
aspartic-type endopeptidase activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity

aspartic-type peptidase activity

aspartic-type endopeptidase activity

binding [inference]

peptide binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MQTPGVLLLILGLLDASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNKVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
134	N-linked (GlcNAc...) asparagine	24090084	G41247ZX G80966KZ G02815KT G55220VL	UniProt GlyGen
255		37442287 38843836	G49108TO	The O-GlcNAc Database
258	N-linked (GlcNAc...) asparagine	24090084 34106099	G31852PQ G41247ZX G02815KT	UniProt GlyGen
260		37442287 38843836	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Collagen degradation	Rattus norvegicus
Insulin receptor recycling	Rattus norvegicus
MHC class II antigen presentation	Rattus norvegicus
Metabolism of Angiotensinogen to Angiotensins	Rattus norvegicus
Neutrophil degranulation	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements