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Tyrosine 3-monooxygenase

Summary

UniProt ID: P24529
Gene Symbol: Th
Gene ID: 21823
Organism: Mus musculus (house mouse)

External Links

GlyGen: P24529
PubChem: P24529
Re-Glyco: P24529

Annotation

Keyword: Catecholamine biosynthesis Cell projection Cytoplasm Cytoplasmic vesicle Direct protein sequencing Iron Metal-binding Monooxygenase Neurotransmitter biosynthesis Nucleus Phosphoprotein Reference proteome Synapse

Gene Ontology (GO)

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	Reference
response to hypoxia	ISO	GO_REF GO_REF
response to hypoxia	IEA	GO_REF
synaptic transmission, dopaminergic	IMP	PMID PMID
synaptic transmission, dopaminergic	IBA	GO_REF
dopamine biosynthetic process from tyrosine	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

metabolic process [inference]

biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

epinephrine metabolic process [inference]

epinephrine biosynthetic process

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

epinephrine metabolic process [inference]

epinephrine biosynthetic process

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process

dopamine biosynthetic process

dopamine biosynthetic process from tyrosine

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

dopamine biosynthetic process from tyrosine

proteinogenic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

dopamine biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

dopamine biosynthetic process from tyrosine

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

dopamine biosynthetic process from tyrosine

proteinogenic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

dopamine biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

dopamine biosynthetic process from tyrosine

intercellular transport [inference]

neurotransmitter loading into synaptic vesicle [inference]

aminergic neurotransmitter loading into synaptic vesicle

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

mating behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

cognition

learning or memory [inference]

behavior [inference]

learning or memory [inference]

locomotory behavior

feeding behavior [inference]

eating behavior

reproductive behavior [inference]

mating behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis [inference]

embryonic camera-type eye morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

embryonic eye morphogenesis [inference]

embryonic camera-type eye morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis [inference]

embryonic camera-type eye morphogenesis

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

anatomical structure regression [inference]

hyaloid vascular plexus regression

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter loading into synaptic vesicle [inference]

aminergic neurotransmitter loading into synaptic vesicle

intercellular transport [inference]

neurotransmitter loading into synaptic vesicle [inference]

aminergic neurotransmitter loading into synaptic vesicle

nitrogen compound transport [inference]

amine transport [inference]

aminergic neurotransmitter loading into synaptic vesicle

establishment of localization in cell [inference]

neurotransmitter loading into synaptic vesicle [inference]

aminergic neurotransmitter loading into synaptic vesicle

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF GO_REF
nucleus	IDA	PMID
nucleus	IEA	GO_REF GO_REF
cytoplasm	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

pigment granule membrane [inference]

melanosome membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
monooxygenase activity	ISO	GO_REF
monooxygenase activity	IEA	GO_REF
tyrosine 3-monooxygenase activity	ISS	GO_REF
tyrosine 3-monooxygenase activity	ISO	GO_REF GO_REF
tyrosine 3-monooxygenase activity	TAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tyrosine 3-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tyrosine 3-monooxygenase activity

binding [inference]

protein binding [inference]

small molecule binding

oxygen binding

ion binding [inference]

cation binding [inference]

dopamine binding

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding [inference]

catecholamine binding [inference]

dopamine binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPTPSASSPQPKGFRRAVSEQDTKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAVASAEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRALKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAFQLLERYCGYREDSIPQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQDELHTLTQALSAIS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites