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Degenerin mec-4

Summary

UniProt ID: P24612
Gene Symbol: T01C8.7 mec-13 mec-4
Gene ID: 181728
Organism: Caenorhabditis elegans

External Links

Re-Glyco: P24612

Annotation

Keyword: 3D-structure Cell projection Glycoprotein Neurodegeneration Potassium transport Reference proteome Sodium channel Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
potassium ion transport
mechanosensory behavior	IMP	PMID PMID
mechanosensory behavior	IGI	PMID
response to mechanical stimulus	IMP	PMID
sodium ion transmembrane transport	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

behavior [inference]

mechanosensory behavior

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

positive regulation of behavior [inference]

positive regulation of mechanosensory behavior

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

negative regulation of reproductive process [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

regulation of mechanosensory behavior [inference]

positive regulation of mechanosensory behavior

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of mechanosensory behavior

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of male mating behavior [inference]

regulation of turning behavior involved in mating [inference]

negative regulation of turning behavior involved in mating

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of mechanosensory behavior [inference]

positive regulation of mechanosensory behavior

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of detection of mechanical stimulus involved in sensory perception of touch

positive regulation of behavior [inference]

positive regulation of mechanosensory behavior

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

regulation of reproductive process [inference]

regulation of male mating behavior [inference]

regulation of turning behavior involved in mating [inference]

negative regulation of turning behavior involved in mating

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

negative regulation of reproductive process [inference]

negative regulation of male mating behavior [inference]

negative regulation of turning behavior involved in mating

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
membrane	IDA	PMID
membrane	IEA	GO_REF GO_REF
axon	IDA	PMID
axon	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane

leading edge membrane [inference]

neuron projection membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying 1 entry
GO Term	Evidence Code	Reference
ligand-gated sodium channel activity	IDA	PMID PMID PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSWMQNLKNYQHLRDPSEYMSQVYGDPLAYLQETTKFVTEREYYEDFGYGECFNSTESEVQCELITGEFDPKLLPYDKRLAWHFKEFCYKTSAHGIPMIGEAPNVYYRAVWVVLFLGCMIMLYLNAQSVLDKYNRNEKIVDIQLKFDTAPFPAITLCNLNPYKASLATSVDLVKRTLSAFDGAMGKAGGNKDHEEEREVVTEPPTTPAPTTKPARRRGKRDLSGAFFEPGFARCLCGSQGSSEQEDKDEEKEEELLETTTKKVFNINDADEEWDGMEEYDNEHYENYDVEATTGMNMMEECQSERTKFDEPTGFDDRCICAFDRSTHDAWPCFLNGTWETTECDTCNEHAFCTKDNKTAKGHRSPCICAPSRFCVAYNGKTPPIEIWTYLQGGTPTEDPNFLEAMGFQGMTDEVAIVTKAKENIMFAMATLSMQDRERLSTTKRELVHKCSFNGKACDIEADFLTHIDPAFGSCFTFNHNRTVNLTSIRAGPMYGLRMLVYVNASDYMPTTEATGVRLTIHDKEDFPFPDTFGYSAPTGYVSSFGLRLRKMSRLPAPYGDCVPDGKTSDYIYSNYEYSVEGCYRSCFQQLVLKECRCGDPRFPVPENARHCDAADPIARKCLDARMNDLGGLHGSFRCRCQQPCRQSIYSVTYSPAKWPSLSLQIQLGSCNGTAVECNKHYKENGAMVEVFYEQLNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTCCEFVFLFLETAYMSAEHNYSLYKKKKAEKAKKIASGSF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
335	N-linked (GlcNAc...) asparagine	UniProt
356	N-linked (GlcNAc...) asparagine	UniProt
480	N-linked (GlcNAc...) asparagine	UniProt
484	N-linked (GlcNAc...) asparagine	UniProt
503	N-linked (GlcNAc...) asparagine	UniProt
671	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Sensory perception of salty taste	Caenorhabditis elegans
Stimuli-sensing channels	Caenorhabditis elegans

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:326	ischemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements