GlyCosmos Portal

Submissions

C-X-C chemokine receptor type 2

Summary

UniProt ID

P25025

Gene Symbol

CXCR2
IL8RB

Gene ID

3579

Organism

Homo sapiens (human)

External Links

PubChem: P25025
The Human Metabolome Database: HMDBP07642
Re-Glyco: P25025

Annotation

Keyword

3D-structure
Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
membrane
secretory granule membrane
nucleoplasm
external side of plasma membrane
cell surface
microtubule cytoskeleton
mast cell granule
mitotic spindle
plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 23 in total

1

2

3

Next ›

Last »
GO Term
positive regulation of cell population proliferation
neutrophil chemotaxis
positive regulation of angiogenesis
positive regulation of neutrophil chemotaxis
acute inflammatory response to antigenic stimulus
negative regulation of neutrophil apoptotic process
interleukin-8-mediated signaling pathway
metanephric tubule morphogenesis
positive regulation of cytosolic calcium ion concentration
positive regulation of cardiac muscle cell apoptotic process

Displaying **all 6** entries
GO Term
G protein-coupled receptor activity
interleukin-8 receptor activity
interleukin-8 binding
C-X-C chemokine receptor activity
C-C chemokine binding
C-C chemokine receptor activity

Annotation information from UniProt.

Sequence

MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
22	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Chemokine receptors bind chemokines	Homo sapiens
G alpha (i) signalling events	Homo sapiens
Neutrophil degranulation	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060973	WHIM syndrome 2	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources
DOID:559	acute pyelonephritis	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources