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MIRAGE
Tumor necrosis factor receptor superfamily member 6

Summary
UniProt ID
P25445
Gene Symbol
  • APT1
  • FAS
  • FAS1
  • TNFRSF6
Gene ID
355
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P25445
PubChem
P25445
RaftProt
P25445
Re-Glyco
P25445
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Calmodulin-binding
  • Cell membrane
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Palmitate
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 9 entries
GO Term
plasma membrane
cytosol
external side of plasma membrane
cell surface
death-inducing signaling complex
CD95 death-inducing signaling complex
membrane raft
extracellular exosome
nuclear body
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 12 in total
Position Description PubMed ID GlyTouCan ID Source
28 O-linked (GalNAc...) threonine
38
39
40
42
43
46
118 N-linked (GlcNAc...) asparagine
132
136 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 7 entries
Pathway Name Organism
CASP8 activity is inhibited Homo sapiens
Dimerization of procaspase-8 Homo sapiens
FasL/ CD95L signaling Homo sapiens
Ligand-dependent caspase activation Homo sapiens
RIPK1-mediated regulated necrosis Homo sapiens
Regulation by c-FLIP Homo sapiens
TP53 Regulates Transcription of Death Receptors and Ligands Homo sapiens
Disease
Displaying entries 11 - 20 of 20 in total
DO ID Disease Name Source
DOID:1909 melanoma
DOID:2377 multiple sclerosis
DOID:2378 relapsing-remitting multiple sclerosis
DOID:4450 renal cell carcinoma
DOID:526 human immunodeficiency virus infectious disease
DOID:6688 autoimmune lymphoproliferative syndrome
DOID:7148 rheumatoid arthritis
DOID:8552 chronic myeloid leukemia
DOID:9074 systemic lupus erythematosus
DOID:9119 acute myeloid leukemia
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025