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Guidelines

MIRAGE

Mediator of replication checkpoint protein 1

Summary

UniProt ID

P25588

Gene Symbol

MRC1
YCL061C
YCL61C/YCL60C

Gene ID

[850297]

Organism

Saccharomyces cerevisiae S288C

External Links

GlyGen: P25588
PubChem: P25588
O-GlcNAcAtlas: P25588
Re-Glyco: P25588

Annotation

Keyword: 3D-structure Coiled coil DNA replication Nucleus Phosphoprotein Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

1

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GO Term	Evidence Code	Reference
DNA replication checkpoint signaling	IMP	PMID PMID PMID
telomere maintenance	IMP	PMID
DNA replication	IMP	PMID
DNA repair	IMP	PMID
DNA repair	IGI	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling

mitotic DNA replication checkpoint signaling

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cell cycle process [inference]

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

heterochromatin organization [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

telomere organization [inference]

telomere maintenance

maintenance of DNA repeat elements

cellular component assembly [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

cellular response to osmotic stress

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

response to abiotic stimulus [inference]

response to osmotic stress [inference]

cellular response to osmotic stress

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling

mitotic DNA replication checkpoint signaling

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling

mitotic DNA replication checkpoint signaling

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of nuclear cell cycle DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of nuclear cell cycle DNA replication

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling

mitotic DNA replication checkpoint signaling

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling

mitotic DNA replication checkpoint signaling

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of nuclear cell cycle DNA replication

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling

mitotic DNA replication checkpoint signaling

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling

mitotic DNA replication checkpoint signaling

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA damage checkpoint signaling [inference]

mitotic G2/M transition checkpoint [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
chromosome, telomeric region	IEA	GO_REF
nucleus	IEA	GO_REF
nucleus	HDA	PMID
replication fork protection complex	IDA	PMID
nuclear periphery	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

replication fork protection complex

cellular anatomical structure [inference]

replication fork [inference]

nuclear replication fork

nuclear periphery

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying 1 entry
GO Term	Evidence Code	Reference
anaphase-promoting complex binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding [inference]

anaphase-promoting complex binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDDALHALSSLTAKKRTTTYKKVAVPILDENDNTNGNGPNDIDNPPELTGNGFLFANATLNRVKNRLEGKKAPEQNHNNGKDRSENSLPTQLISNLYDGGEELEKSEVKDNSYSEKNVSSSFTQTQRIPVSIQQDKVFNVPIHSVNDGKPTQLIKEDGLVNETSQALKTPLTTGRPGATQRIDSSGATSQTQPIKSIEPQSQIITTSSNHSNALSPKIPIIPTELIGTSPLFQSIQNRGPDTQMDVPPQTAHDEDKTQAIGIPQATHQEQKTQIDTVAQTLQDEVPHTLKIREIQSELASEDSKREKARNVEYKKPQKPIPTKKFFSKESFLADFDDSSSNEDDDIKLENAHPKPVQNDDELHENKSVELNLTDETRINEKRVPLLSSYANNLKREIDSSKCITLDLDSDSDEYGDDDMDSIKLSKDESVLPISQLSKATILNLKARLSKQNQKLSQRPNKSKDPKVDHNVLLNTLRKASRKQILDHQKEVIETKGLKLEDMAKEKEIVENLLEQEILRNKRIRQKEKRREKLEENDFQLNAHDSGSDSGSESSGFALSGNEIADYESSGSENDNRRESDSEKEDDEIILKQKKSHHVKHIINESDSDTEVEAKPKEKADESLPKRIAINLGHYGDNIGEDTDKFQETNVLDTQNIEEVMAERNTIENEVKDDVYVNEEADEAIRRQLIDKEKLQLKQKEKEHEAKIKELKKRGVTNFFEMEAEESEDEWHGIGGADGEGSDDYDSDLEKMIDDYSKNNFNPHEIREMLAAENKEMDIKMINKILYDIKNGGFRNKRAKNSLELELSDDDEDDVLQQYRLKRRELMRKRRLEIGDDAKLVKNPKSSAFFESMVEDIIEYKNPFGAEEEYNLDITSTATDLDTQDNSINVGDNTGNNEQKPVDQKNKKVIISEDFVQKSLSFLKSNNYEDFETDKELSRIQHGNDEAIEDLYTLKQNSSIKSFTNSQTDSTTSKTVNTIIDLEKRPEDEDEVENGDTSLVGVFKHPSIIKSFASRTDINDKFKEGNKTVKILKSYKTVGSSKASITYMGKTRKLIAPKRKTEGSHRYHHDHHNKKMKMKTKTKSNKLFESGQDSFDN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
131			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Activation of ATR in response to replication stress	Saccharomyces cerevisiae

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026