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Dorsal-ventral patterning protein tolloid

Summary

UniProt ID: P25723
Gene Symbol: CG6868 tld
Gene ID: 42945
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: P25723
Re-Glyco: P25723

Annotation

Keyword: Calcium Cleavage on pair of basic residues Developmental protein Disulfide bond EGF-like domain Glycoprotein Metal-binding Metalloprotease Reference proteome Repeat Signal Zinc Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
proteolysis	IDA	PMID PMID
proteolysis	IEA	GO_REF
maternal specification of dorsal/ventral axis, oocyte, soma encoded	IMP	PMID
amnioserosa formation	IMP	PMID
imaginal disc-derived wing vein morphogenesis	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

photoreceptor cell fate specification [inference]

R8 cell fate specification

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

axis specification [inference]

oocyte axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

dorsal/ventral axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification [inference]

oocyte dorsal/ventral axis specification [inference]

maternal specification of dorsal/ventral axis, oocyte, soma encoded

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing vein morphogenesis

anatomical structure formation involved in morphogenesis [inference]

amnioserosa formation

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

photoreceptor cell fate specification [inference]

R8 cell fate specification

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

Displaying 1 entry
GO Term	Evidence Code	Reference
obsolete extracellular space

GO Hierarchy

cellular component

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
metalloendopeptidase activity	IDA	PMID PMID PMID PMID PMID PMID PMID
metalloendopeptidase activity	IMP	PMID
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF GO_REF
calcium ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

collagen binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKGMRLMPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGEDFDAVTPFPGYLKSMYSSETGSDHLLPPSRLI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	Source
176	N-linked (GlcNAc...) asparagine	UniProt
441	N-linked (GlcNAc...) asparagine	UniProt
543	N-linked (GlcNAc...) asparagine	UniProt
644	N-linked (GlcNAc...) asparagine	UniProt
677	N-linked (GlcNAc...) asparagine	UniProt
791	N-linked (GlcNAc...) asparagine	UniProt
864	N-linked (GlcNAc...) asparagine	UniProt
918	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Anchoring fibril formation	Drosophila melanogaster
Collagen biosynthesis and modifying enzymes	Drosophila melanogaster
Crosslinking of collagen fibrils	Drosophila melanogaster
Degradation of the extracellular matrix	Drosophila melanogaster

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