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3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Summary

UniProt ID: P26439
Gene Symbol: HSD3B2 HSDB3B
Gene ID: 3284
Organism: Homo sapiens (human)

External Links

PubChem

P26439

SwissLipids

SLP:000001296

The Human Metabolome Database

HMDBP04404

The O-GlcNAc Database

P26439

Re-Glyco

P26439

Annotation

Keyword: Alternative splicing Congenital adrenal hyperplasia Disease variant Endoplasmic reticulum Isomerase Lipid metabolism Mitochondrion Multifunctional enzyme NAD Oxidoreductase Proteomics identification Reference proteome Steroidogenesis Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
steroid biosynthetic process	IDA	PMID
steroid biosynthetic process	IMP	PMID
steroid biosynthetic process	IBA	GO_REF
steroid biosynthetic process	IEA	GO_REF GO_REF
androgen biosynthetic process	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

hormone metabolic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

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GO Term	Evidence Code	Reference
nucleolus
cytoplasm	IBA	GO_REF
mitochondrial inner membrane	ISS	GO_REF
mitochondrial intermembrane space	ISS	GO_REF
endoplasmic reticulum	NAS	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

smooth endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

bounding membrane of organelle [inference]

smooth endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

ciliary transition zone

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular membraneless organelle [inference]

nucleolus

cytoskeleton [inference]

microtubule cytoskeleton

intercellular bridge

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GO Term	Evidence Code	Reference
3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity	IDA	PMID
3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity	IMP	PMID
3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity	IEA	GO_REF GO_REF
steroid Delta-isomerase activity	IDA	PMID
steroid Delta-isomerase activity	IMP	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing C=C bonds [inference]

steroid Delta-isomerase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEGDILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDTLYTCALRPTYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLDSRWSLPLTLMYWIGFLLEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
263		38253038	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Androgen biosynthesis	Homo sapiens
Glucocorticoid biosynthesis	Homo sapiens
Mineralocorticoid biosynthesis	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10892	hypospadias	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements