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MIRAGE
NKG2-D type II integral membrane protein
Summary
- UniProt ID
- P26718
- Gene Symbol
-
- D12S2489E
- KLRK1
- NKG2D
- Gene ID
- 100528032
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative splicing
- Cell membrane
- Differentiation
- Disulfide bond
- Glycoprotein
- Innate immunity
- Lectin
- Receptor
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| membrane |
| external side of plasma membrane |
| cell surface |
| GO Term |
|---|
| natural killer cell activation |
| T cell costimulation |
| negative regulation of GTPase activity |
| natural killer cell mediated cytotoxicity |
| positive regulation of natural killer cell mediated cytotoxicity |
| GO Term |
|---|
| signaling receptor activity |
| carbohydrate binding |
| MHC class Ib receptor activity |
| identical protein binding |
| MHC class I protein binding |
Sequence
MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| DAP12 interactions | Homo sapiens |
| DAP12 signaling | Homo sapiens |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:321 | HTLV-1-associated myelopathy/tropical spastic paraparesis |
