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Protein disulfide-isomerase A3

Summary

UniProt ID: P27773
Gene Symbol: Erp Erp60 Grp58 Pdia3
Gene ID: 14827
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003531
PubChem: P27773
RaftProt: P27773
Re-Glyco: P27773

Annotation

Keyword: Acetylation Adaptive immunity Direct protein sequencing Disulfide bond Endoplasmic reticulum Isomerase Methylation Phosphoprotein Redox-active center Reference proteome Repeat Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
adaptive immune response
peptide antigen assembly with MHC class I protein complex	ISO	GO_REF
peptide antigen assembly with MHC class I protein complex	IEA	GO_REF
protein folding	IBA	GO_REF
response to endoplasmic reticulum stress

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

protein folding

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

immune response [inference]

adaptive immune response

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

response to lipid [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

response to interleukin-7 [inference]

cellular response to interleukin-7

response to oxygen-containing compound [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein folding

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein folding

regulation of protein folding [inference]

positive regulation of protein folding

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
acrosomal vesicle	ISO	GO_REF
extracellular region	ISO	GO_REF GO_REF
extracellular region	IEA	GO_REF
obsolete extracellular space
endoplasmic reticulum	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

cellular anatomical structure [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
protein disulfide isomerase activity	ISS	GO_REF
protein disulfide isomerase activity	ISO	GO_REF
protein disulfide isomerase activity	IEA	GO_REF GO_REF
peptidase activity	ISO	GO_REF
protein-disulfide reductase activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity

protein-disulfide reductase (glutathione) activity

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [inference]

protein-disulfide reductase (glutathione) activity

hydrolase activity [inference]

peptidase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

protein-disulfide reductase activity

protein-disulfide reductase (glutathione) activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

lncRNA binding

protein binding [inference]

signaling receptor binding [inference]

MHC protein binding [inference]

MHC class I protein binding

identical protein binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
90				GlycoProtDB

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Mus musculus
Calnexin/calreticulin cycle	Mus musculus
ER-Phagosome pathway	Mus musculus