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Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

Summary

UniProt ID

P28241

Gene Symbol

IDH2
O3326
YOR136W
YOR3326W

Gene ID

[854303]

Organism

Saccharomyces cerevisiae S288C

External Links

GlyGen: P28241
PubChem: P28241
O-GlcNAcAtlas: P28241
Re-Glyco: P28241

Annotation

Keyword: 3D-structure Allosteric enzyme Direct protein sequencing Magnesium Manganese Metal-binding Mitochondrion NAD Oxidoreductase Phosphoprotein RNA-binding Reference proteome Transit peptide Tricarboxylic acid cycle

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
tricarboxylic acid cycle	TAS	PMID
tricarboxylic acid cycle	IDA	PMID
tricarboxylic acid cycle	IBA	GO_REF
tricarboxylic acid cycle	IEA	GO_REF
isocitrate metabolic process	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

tricarboxylic acid cycle

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

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GO Term	Evidence Code	Reference
mitochondrion	RCA	GO_REF
mitochondrion	IDA	PMID PMID
mitochondrion	IBA	GO_REF
mitochondrion	HDA	PMID PMID PMID PMID
mitochondrial matrix	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle heteromeric enzyme complex [inference]

isocitrate dehydrogenase complex (NAD+)

oxidoreductase complex [inference]

isocitrate dehydrogenase complex (NAD+)

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

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GO Term	Evidence Code	Reference
magnesium ion binding	IEA	GO_REF
RNA binding
isocitrate dehydrogenase (NAD+) activity	RCA	GO_REF
isocitrate dehydrogenase (NAD+) activity	IDA	PMID
isocitrate dehydrogenase (NAD+) activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NAD+) activity

binding [inference]

nucleic acid binding [inference]

RNA binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLRNTFFRNTSRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
5			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Citric acid cycle (TCA cycle)	Saccharomyces cerevisiae

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050709	early infantile epileptic encephalopathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements