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Protein-lysine 6-oxidase

Summary

UniProt ID: P28300
Gene Symbol: LOX hCG_37363
Gene ID: 4015
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011644

GlyConnect

Protein-lysine 6-oxidase

GlyGen

P28300

PubChem

P28300

The Human Metabolome Database

HMDBP00696

The O-GlcNAc Database

P28300

O-GlcNAcAtlas

P28300

Re-Glyco

P28300

Annotation

Keyword: Aortic aneurysm Copper Disease variant Disulfide bond Glycoprotein LTQ Metal-binding Oxidoreductase Proteomics identification Reference proteome Secreted Signal Sulfation TPQ

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	Reference
osteoblast differentiation
heart development
response to xenobiotic stimulus	IEA	GO_REF
regulation of gene expression
regulation of striated muscle tissue development

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway [inference]

platelet-derived growth factor receptor-beta signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

macromolecule modification [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

muscle cell development

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

elastic fiber assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development

animal gross anatomical part developmental process [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

connective tissue development

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

muscle cell development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone

response to chemical [inference]

response to xenobiotic stimulus

response to hormone [inference]

response to steroid hormone

response to lipid [inference]

response to steroid hormone

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

response to chemokine [inference]

cellular response to chemokine

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of muscle organ development [inference]

regulation of striated muscle tissue development

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development

regulation of multicellular organismal development [inference]

regulation of bone development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway [inference]

platelet-derived growth factor receptor-beta signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of bone development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	TAS	Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF GO_REF
collagen trimer	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

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GO Term	Evidence Code	Reference
protein-lysine 6-oxidase activity	ISS	GO_REF
protein-lysine 6-oxidase activity	EXP	PMID
protein-lysine 6-oxidase activity	TAS	PMID
protein-lysine 6-oxidase activity	IDA	PMID
protein-lysine 6-oxidase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [inference]

protein-lysine 6-oxidase activity

catalytic activity, acting on a protein [inference]

protein-lysine 6-oxidase activity

binding [inference]

small molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

protein-containing complex binding [inference]

collagen binding

molecular adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 16 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
81	N-linked (GlcNAc...) asparagine	23090970 24190977 29391424 29741879 30237853 37074911	G64394MX G99668VU G06330RB G22310AV G48414YA G80223IX G25418HZ G84452RH G83460ZZ G46503DX G80920RR G90659AW G45504EY G62765YT G31852PQ G41247ZX G02815KT	GlycoProtDB UniProt GlyGen GlyConnect
89		23584533 30459171	G43417UB G57321FI	GlyGen
97	N-linked (GlcNAc...) asparagine	23345538 37074911	G14943SF G26915XM G63543FL G45395BF G27058EU	UniProt GlyGen GlyConnect
106		23584533	G57321FI	GlyGen
113		23584533	G57321FI	GlyGen
120		23584533	G57321FI	GlyGen
123		23584533	G57321FI	GlyGen
129		23584533 25813380		GlyGen
130		23584533	G57321FI	GlyGen
131		23584533	G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Crosslinking of collagen fibrils	Homo sapiens
Elastic fibre formation	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:1838	Menkes disease	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources
DOID:13359	Ehlers-Danlos syndrome	Alliance of Genome Resources
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements