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Sodium-dependent proline transporter

Summary

UniProt ID: P28573
Gene Symbol: Slc6a7 Prot
Gene ID: 117100
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: P28573
Re-Glyco: P28573

Annotation

Keyword: Amino-acid transport Cell membrane Glycoprotein Neurotransmitter transport Phosphoprotein Reference proteome Symport Synapse Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
neurotransmitter transport
proline transport	ISO	GO_REF
proline transport	IDA	PMID PMID
proline transport	IBA	GO_REF
protein catabolic process	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

transmembrane transport [inference]

amino acid transmembrane transport [inference]

proline transmembrane transport

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

neurotransmitter transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

proline transmembrane transport

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

neutral amino acid transport [inference]

glycine transport [inference]

glycine import across plasma membrane

proline transport

L-amino acid transport [inference]

proline transport

organic cation transport [inference]

glycine transport [inference]

glycine import across plasma membrane

proline transport

organic anion transport [inference]

carboxylic acid transport [inference]

L-amino acid transport [inference]

proline transport

glycine transport [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

L-amino acid transport [inference]

proline transport

glycine transport [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

transmembrane transport [inference]

amino acid transmembrane transport [inference]

proline transmembrane transport

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

nitrogen compound transport [inference]

L-amino acid transport [inference]

proline transport

glycine transport [inference]

glycine import across plasma membrane

proline transmembrane transport

import into cell [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

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GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
synaptic vesicle membrane	IEP	PMID
synaptic vesicle membrane	IDA	PMID
presynaptic membrane	IDA	PMID
synapse	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse

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GO Term	Evidence Code	Reference
proline:sodium symporter activity	ISS	GO_REF
proline:sodium symporter activity	ISO	GO_REF
proline:sodium symporter activity	IDA	PMID
proline:sodium symporter activity	IBA	GO_REF
L-proline transmembrane transporter activity	ISO	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

proline:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

proline:sodium symporter activity

organic acid:sodium symporter activity [inference]

proline:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

proline:sodium symporter activity

organic acid:sodium symporter activity [inference]

proline:sodium symporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

proline:sodium symporter activity

neutral L-amino acid transmembrane transporter activity [inference]

L-proline transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-proline transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

proline:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

proline:sodium symporter activity

organic acid:sodium symporter activity [inference]

proline:sodium symporter activity

carboxylic acid transmembrane transporter activity [inference]

proline:sodium symporter activity

L-amino acid transmembrane transporter activity [inference]

L-proline transmembrane transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKKLQEAHLRKPVTPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWSRYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVIYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAIDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEEESMM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
182	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Creatine metabolism	Rattus norvegicus
SLC-mediated transport of neurotransmitters	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements