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Meprin A subunit alpha

Summary

UniProt ID: P28825
Gene Symbol: Mep1a
Gene ID: 17287
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003539
GlyGen: P28825
Re-Glyco: P28825

Annotation

Keyword: Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Metal-binding Metalloprotease Reference proteome Signal Transmembrane helix Zinc Zymogen

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
epidermal growth factor receptor ligand maturation	ISO	PMID
signaling receptor ligand precursor processing	ISO	PMID
signaling receptor ligand precursor processing	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
plasma membrane	ISO	PMID
membrane	IDA	PMID
membrane	IEA	GO_REF GO_REF GO_REF
meprin A complex	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

meprin A complex

cellular anatomical structure [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF GO_REF
metallopeptidase activity	ISO	PMID
metallopeptidase activity	IEA	GO_REF
zinc ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Site Annotations

Displaying 1 entry
Position	Description
601	Not glycosylated

Annotation information from UniProt.

Sequence

MLWIQPACLLSLIFSAHIAAVSIKHLLNGSDHDTDVGEQKDIFEINLAAGLNLFQGDILLPRTRNAMRDPSSRWKLPIPYILADNLELNAKGAILHAFEMFRLKSCVDFKPYEGESSYIIFQKLSGCWSMIGDQQVGQNISIGEGCDFKATIEHEILHALGFFHEQSRTDRDDYVNIWWDQIITDYEHNFNTYDDNTITDLNTPYDYESLMHYGPFSFNKNESIPTITTKIPEFNTIIGQLPDFSAIDLIRLNRMYNCTATHTLLDHCDFEKTNVCGMIQGTRDDADWAHGDSSQPEQVDHTLVGQCKGAGYFMFFNTSLGARGEAALLESRILYPKRKQQCLQFFYKMTGSPADRFEVWVRRDDNAGKVRQLAKIQTFQGDSDHNWKIAHVTLNEEKKFRYVFLGTKGDPGNSSGGIYLDDITLTETPCPAGVWTIRNISQILENTVKGDKLVSPRFYNSEGYGVGVTLYPNGRITSNSGFLGLTFHLYSGDNDAILEWPVENRQAIMTILDQEADTRNRMSLTLMFTTSKNQTSSAINGSVIWDRPSKVGVYDKDCDCFRSLDWGWGQAISHQLLKRRNFLKGDSLIIFVDFKDLTHLNRTEVPASARSTMPRGLLLQGQESPALGESSRKAMLEESLPSSLGQRHPSRQKRSVENTGPMEDHNWPQYFRDPCDPNPCQNEGTCVNVKGMASCRCVSGHAFFYAGERCQAMHVHGSLLGLLIGCIAGLIFLTFVTFSTTNGKLRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
28	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
139	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
221	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
257	N-linked (GlcNAc...) asparagine	17040911	G79421NO G35510GA G05622OS G44437FL G04062KZ G98147MD G02281EI G13749ZZ G06337UR G27336AY G22267GY	GlycoProtDB UniProt GlyGen
317	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
413	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
439	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
533	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
540	N-linked (GlcNAc...) asparagine	17040911		GlycoProtDB UniProt GlyGen
601				GlycoProtDB