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Acrosin [Cleaved into: Acrosin light chain; Acrosin heavy chain]

Summary

UniProt ID

P29293

Gene Symbol

Gene ID

24163

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P29293
Re-Glyco: P29293

Annotation

Keyword: Disulfide bond Glycoprotein Reference proteome Serine protease Signal Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
acrosome matrix dispersal	IMP	PMID
proteolysis	ISO	GO_REF
proteolysis	IEA	GO_REF
activation of adenylate cyclase activity	ISS	GO_REF
activation of adenylate cyclase activity	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

acrosome matrix dispersal

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

acrosome matrix dispersal

protein metabolic process [inference]

proteolysis

protein catabolic process

acrosome matrix dispersal

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process

acrosome matrix dispersal

reproductive process [inference]

acrosome reaction

fertilization [inference]

single fertilization

multicellular organismal reproductive process [inference]

penetration of zona pellucida

multicellular organismal process [inference]

multi-multicellular organism process [inference]

penetration of zona pellucida

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone

response to chemical [inference]

response to hormone [inference]

response to steroid hormone

response to lipid [inference]

response to steroid hormone

biological regulation [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

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GO Term	Evidence Code	Reference
acrosomal vesicle	ISO	GO_REF
acrosomal vesicle	TAS	PMID
acrosomal vesicle	IDA	PMID
acrosomal vesicle	IEA	GO_REF GO_REF
Golgi-associated vesicle	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

acrosomal matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

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GO Term	Evidence Code	Reference
amidase activity	ISS	GO_REF
amidase activity	ISO	GO_REF
serine-type endopeptidase activity	ISS	GO_REF
serine-type endopeptidase activity	ISO	GO_REF
serine-type endopeptidase activity	TAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

amidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

small molecule binding [inference]

monosaccharide binding [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVEMLPTVVALVLAVSVVAKDNTTCDGPCGLRFRQNPQAGIRIVGGQTSSPGAWPWMVSLQIFTSHNSRRYHACGGSLLNSHWVLTAAHCFDNKKKVYDWRLVFGAHEIEYGRNKPVKEPQQERYVQKIVIHEKYNAVTEGNDIALLKVTPPVTCGDFVGPGCLPHFKSGPPRIPHTCYVTGWGYIKDNAPRPSPVLMEARVDLIDLDLCNSTQWYNGRVTSTNVCAGYPEGKIDTCQGDSGGPLMCRDSVDSPFVIVGITSWGVGCARAKRPGVYTATWDYLDWIASKIGPTALHLIQPATPHPPTTQQPVISFHPPSIHPPWYFQHLSPRPPHLRPPRPLLHQPSSVHTSSAPVIPLLSLLTPVQPVSFTLAAYHTRHHTTLSFARRLQHLIEALKMRTYPIKYPSRYSGPVNYQHRFSTFEPLSNKPSEPLLHS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
22	N-linked (GlcNAc...) asparagine			UniProt
211	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Acrosome Reaction and Sperm:Oocyte Membrane Binding	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements