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Interleukin-12 subunit beta

Summary

UniProt ID

P29460

Gene Symbol

IL12B
NKSF2

Gene ID

3593

Organism

Homo sapiens (human)

External Links

GlyConnect

Interleukin-12 beta chain

GlyGen

P29460

PubChem

P29460

Re-Glyco

P29460

Annotation

Keyword

3D-structure
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
extracellular region
extracellular space
receptor complex
endoplasmic reticulum lumen
cytosol
external side of plasma membrane
late endosome lumen
interleukin-12 complex
interleukin-23 complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 52 in total

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GO Term
regulation of cytokine production
positive regulation of cell population proliferation
cell migration
cytokine-mediated signaling pathway
sexual reproduction
positive regulation of type II interferon production
positive regulation of mononuclear cell proliferation
positive regulation of tissue remodeling
T cell proliferation
positive regulation of T cell proliferation

Displaying **all 8** entries
GO Term
interleukin-12 alpha subunit binding
cytokine receptor activity
cytokine activity
cytokine binding
identical protein binding
protein-containing complex binding
protein heterodimerization activity
interleukin-12 receptor binding

Annotation information from UniProt.

Sequence

MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
135	N-linked (GlcNAc...) asparagine			UniProt GlyGen
222	N-linked (GlcNAc...) asparagine	10899108		UniProt GlyGen
319	C-linked (Man) tryptophan	10207176	G70323CJ	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Interleukin-10 signaling	Homo sapiens
Interleukin-12 signaling	Homo sapiens
Interleukin-23 signaling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060859	salmonellosis	Alliance of Genome Resources
DOID:0111950	immunodeficiency 29	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources